液基细胞学与人乳头瘤状病毒联合检测分析对宫颈癌筛查的临床价值  

The clinical value of liquid-cytology test(LCT) and human papilloma virus(HPV-DNA) for cervical cancer screening

作　　者：黄川英[1] 

机构地区：[1]贵港市人民医院,广西贵港537100

出　　处：《中外医学研究》2011年第35期6-8,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的探讨液基细胞学检查(LCT)、人乳头瘤状病毒(HPV-DNA)检测及两种联合检测对宫颈癌筛查的临床诊断价值。方法用人乳头瘤状病毒(HPV-DNA)检测和液基细胞学测试(LCT)对1565例患者进行了宫颈筛查,最后结合阴道镜活检组织病理结果作为诊断结果。结果在对高级别宫颈上皮内瘤变(CIN)的检测中,HPV-DNA与LCT的敏感性分别为94.26%、90.98%,特异性分别为81.39%、81.11%,而联合两种检测方法几乎可以筛查出所有的CINⅡ以上的病变,敏感性高达99%,明显提高了宫颈病变的检出率。结论 HPV-DNA和LCT检测常用于宫颈癌筛查,联合应用能显著提高筛查效率。Objective To dicuss the clinical value of liquid - based cytology test （ LCT）, human papilloma virus （ HPV - DNA） and their combined analysis for cervical cancer screening. Methods Using two ways of HPV - DNA and LCT to check 1565 women＇s cervixs ,which combined the results of eolposcopy biopsy as the final diagnosis in screening cervical cancer. Results In the high - grade examination of cervical intraepithelial neoplasia（ CIN）, the sensitivity of HPV - DNA and LCT were 94. 26% , 90. 98%, their specificity were 81.39% , 81.11% , and combine two methods,which almost can screening above all of CIN II pathological changes, their sensitivity can high to 99%. It improved the de- tection rate of cervical pathological change obviously. Conclusion Both HPV - DNA test and LCT are valuable for screening cervical cancer. The combined detection by HPV - DNA test and LCT can significantly improve the detection rate in cervical cancer screening.

关 键 词：宫颈肿瘤 人乳头状瘤病毒(HPV-DNA)检测 薄层液基细胞学 筛查 

分 类 号：R737.33[医药卫生—肿瘤]