在抗坏血酸存在下噻二唑类导电聚合物修饰电极测定肾上腺素  

Determination of epinephrine by using a electrode of electropolymerized 5-amino-2-mercapto-1,3,4-thiadiazole film in the presence of ascorbic acid

作　　者：赵常志[1] 刘会[1] 赵影[1] 

机构地区：[1]青岛科技大学化学与分子工程学院,山东青岛266042

出　　处：《辽宁师范大学学报（自然科学版）》2011年第4期482-485,共4页Journal of Liaoning Normal University:Natural Science Edition

基　　金：电分析化学国家重点实验室开放基金项目(SKLEAC201106)

摘　　要：在玻碳电极表面电聚合5-氨基-2-巯基-1,3,4-噻二唑,制备了导电聚合物修饰电极.通过循环伏安法和示差脉冲伏安法研究了肾上腺素和抗坏血酸在该修饰电极上的电化学行为.发现肾上腺素在1.00×10-7～1.20×10-4 mol/L的浓度范围内与其氧化峰电流有良好的线性关系,检测限为3.80×10-8 mol/L.由于肾上腺素和抗坏血酸的电位差达220mV,大量抗坏血酸的存在不干扰肾上腺素的测定.A modified electrode was prepared by electropolymerization of 5-amino-2-mercapto-1,3,4-thiadiazole（AMT） on a glassy carbon electrode with cyclic voltammetry（CV）.The electrochemical response of the modified electrode to epinephrine（EN） and ascorbic acid（AA） were investigated by CV and differential pulse voltammetry（DPV）.DPVs for the mixture of EN and AA showed that they have a potential difference of 240 mV,and EN presented sensitively current response in the presence of AA.Under the optimized conditions,the anodic current increased linearly with the concentration of EN in the range of 1.0×10-7~1.0×10-4 mol/L,and the detection limit was estimated to 3.8×10-8 mol/L.In the presence of AA,EN was determined in the adrenaline hydrochlaride injection with the relative standard deviation of 4.8%（n=5） and the recovery of 98.0~104.6%.

关 键 词：5-氨基-2-巯基-1 3 4-噻二唑 修饰电极 肾上腺素 抗坏血酸 电聚合 

分 类 号：O657.1[理学—分析化学]