补虚颗粒的制备与质量控制  

Preparation and Quality Control Of Buxu Granules

作　　者：李开俊[1] 何宏生[1] 李斌[1] 陈富超[1] 

机构地区：[1]湖北医药学院附属东风总医院,湖北十堰442008

出　　处：《中国药业》2011年第23期30-31,共2页China Pharmaceuticals

摘　　要：目的探讨补虚颗粒剂的制备工艺及合适的质量控制方法。方法采用超声提取法、加热回流法、煎煮法等提取方法制备补虚颗粒;应用薄层色谱(TLC)法分别对补虚颗粒中组分当归及黄芪进行鉴别;采用反相高效液相色谱(RP-HPLC)法对阿魏酸进行含量测定。结果薄层定性方法斑点清晰,分离完全,易于区别;阿魏酸质量浓度在0.208～1.04μg/mL范围内与峰面积线性关系良好,r=0.999 7,平均回收率为98.16%,RSD=1.28%(n=5)。结论补虚颗粒制备工艺简单、可行。所建立的定性及定量方法准确、可靠、重现性好,可作为该制剂的质量控制方法。Objective To study the preparation and quality control of Buxu Granules.Methods Using ultrasonic extraction,heating reflux,boiling act extracting method to prepare Buxu Granules.Buxu Granules＇main ingredients angelica and astragalus were identified by TCL.Using RP-HPLC to determinate ferulic acid.Results The spots were clear and separated completely in the TLC method;there was a good linear relationship between ferulic acid and absorption area value in the range of 0.208-1.04 μg/mL,r=0.999 7.The averge recovery was 98.16%,with RSD=1.28%.Conclusion The method of Buxu Granules preparation is simple and feasible,and identification and determination were accurate and reproducible.It can be used for quality control of the preparation.

关 键 词：补虚颗粒 制备 质量控制 阿魏酸 

分 类 号：R284.1[医药卫生—中药学] R283.6[医药卫生—中医学]