细支气管肺泡癌^(18)F FDG PET/CT SUV值与HRCT形态学的相关性研究  

Study of the Relationship between ^(18)F-FDG PET/CT SUV and HRCT Morphology in Bronchial Alveolar Carcinoma(BAC)

作　　者：何宝明[1] 王志忠[1] 刘晓飞[1] 姚昊[1] 欧阳晓辉[1] 苏家贵[1] 

机构地区：[1]解放军第309医院核医学科,北京100091

出　　处：《科学技术与工程》2011年第35期8858-8861,共4页Science Technology and Engineering

摘　　要：探讨不同类型细支气管肺泡癌的HRCT形态学表现与FDG PET SUV值的相关性。回顾性地分析经病理证实的28例细支气管肺泡癌患者的FDG PET和HRCT的影像资料,分别记录分析其形态学改变特点及FDG摄取程度和摄取特点,同时测量其最大SUV值(SUVmax),将不同形态的细支气管肺泡癌影像与所测得的最大SUV值进行对比研究。28例中单发结节13例,其中磨玻璃密度结节5例,直径1.1—2.8 cm,SUVmax值均<1.5。4例结节边缘可见分叶,2例可见胸膜牵拉、凹陷,2例见血管聚集;8例实性结节,直径1.8—3.8 cm,SUVmax值4.8—8.3。边缘短毛刺7例,分叶7例,支气管充气症6例,空泡症5例,胸膜凹陷症3例,血管集聚症7例,结节堆聚症3例。多发结节型9例,其中4例为粟粒性结节,5例表现为2个以上结节,磨玻璃密度结节、小的粟粒结节(<3 mm)无FDG摄取,融合结节,大于3 mm的粟粒结节可见FDG摄取,SUVmax值在2.1—3.9。肺炎型6例,单肺叶受累4例,双肺叶受累2例,表现为病变肺叶内大片状实变影,7例可见支气管充气、支气管扭曲、僵硬,1例见空洞影,1例见支气管截断,3例见支气管管壁不规则增厚,PET显示实变病灶内FDG摄取不均匀增高,最大SUVmax值4.5—11.8。说明细支气管肺泡癌HRCT所示的形态学表现与PET所测得SUV值之间存在一定的相关性。磨玻璃密度影、小于3 mm的粟粒结节影大多数无异常FDG摄取,肺炎型和肿块型则多数具有较高的FDG摄取。To investigation of the relationship between 18F-FDG PET/CT standardized uptake value（SUV）and HRCT morphology in BAC,in total 28 histologically diagnosed BAC patients underwent 18F-FDG PET/CT and HRCT were entered into this retrospective study.The morphology and the radioactive finding were observed and the max standardized uptake value SUV were measured. It is resulted there were three type of morphology of BAC;13 case of.solitary nodule which include ground-glass opacity nodule GGO（n=5） and solid nodule（n=8）.The GGO nodules that the diameter was usually 1.1—2.8cm and the mean values SUVmax was less than 1.5,that had the characters of morphology such as lobulation（n=4）,pleural indentation（n=2）,vascular aggregated sign（n=2）.The solid nodules which had a higher uptake（SUVmax： 4.8—8.3）,diameter 1.8—3.8 cm with short speculation（n=8）,lobulation（n=7）,aerated bronchi（n=6）,vacuoles（n=5）,pleural indentation（n=3）.Vascular aggregated sign（n=7）,nodules accumulate（n=3）.There were 9 cases of multi-nodules which included 4 case of Miliary nodules noduled and 5 case of the number of nodules more than 2.GGO and samll Miliary nodules（nodule which diameter 3 mm） were without FDG uptake,melt noudle and larger miliary nodules（nodule which diameter 3 mm） had FDG uptake,the SUVmax 2.1—3.9.The pneumonia type：The consolidation was observed in one（n=4）,or two lobes（n=2）,with ＂aerated bronchi＂ sign（n=7）,or ＂honeycomb＂ sign（n=1）,bronchial marginal cutoff（n=1）.Radioactive distribution was inhomogeneous,SUVmax 4.5—11,FDG uptake of part lesions is negative results.It conclused there are a correlation between F-FDG PET/CT SUV and HRCT morphology in Bronchial alveolar carcinoma（BAC）.Miliary nodules nodule which diameter less than 3 mm and ground-glass opacity normally are without FDG uptake meanwhile the type of pneumonia and mass almost have higher uptake.

关 键 词：支气管肺泡癌 高分辨率计算机断层扫描(HRCT) 正电子发射断层扫描(PET) 18-氟代脱氧葡萄糖(18F-FDG) 标准摄取值SUV 

分 类 号：R734.2[医药卫生—肿瘤]