TACE联合三维适形放疗治疗中晚期原发性肝癌疗效观察  

Clinical observation of the effect of TACE combined with three dimensional conformal radiotherapy on patients with advanced hepatocellular carcinoma

作　　者：谭新劲[1] 任丽[1] 刘晋湘[1] 刘云[1] 

机构地区：[1]成都市解放军第452医院放疗科,610021

出　　处：《实用肝脏病杂志》2011年第6期433-435,共3页Journal of Practical Hepatology

摘　　要：目的探讨肝动脉灌注栓塞化疗(TACE)联合三维适形放疗(3-DCRT)治疗中晚期原发性肝癌的疗效。方法 87例患者随机分为TACE联合3-DCRT治疗组45例和TACE治疗组42例。联合组先进行TACE治疗1～2次,4～6周后行3-DCRT,分割剂量2.6～3.2 Gy,总剂量为48～60 Gy。TACE组行TACE治疗2～3次。结果联合组近期总有效率为86.7%,TACE组为66.7%(P<0.05);两组1年、2年、3年生存率分别为73.3%、53.3%、35.6%和59.5%、31.0%、14.3%,其中2、3年生存率差异具有统计学意义(P<0.05)。结论 TACE联合3-DCRT治疗中晚期原发性肝癌具有较好的疗效,不良反应少。Objective To investigate the clinical effects of transcatheter arterial chemoembolization（TACE） combined with three dimensional conformal radiotherapy（3-DCRT）on patients with advanced hepatocellular carcinoma.Methods A total of 87 patients with advanced hepatocellular carcinoma were randomly divided into TACE/3-DCRT group（n=45）and TACE group（n=42）.The patients in TACE/3-DCRT group were treated first with TACE and then 3-DCRT,the dose was 2.6～3.2Gy each time,and the total dose was 48～60Gy.The patients in TACE group were given TACE only.Results The total response（CR＋PR） were 86.7% in TACE/3-DCRT group,much higher than 66.7% in TACE group（P0.05）;The 1,2,3-year survival rates were 73.3%,53.3%,35.6% and 59.5%,31.0%,14.3%,respectively in the two groups.Conclusions TACE combined with 3-DCRT is more effective than TACE only,and the side effects are tolerated.

关 键 词：肝肿瘤 三维适形放疗 肝动脉灌注栓塞 

分 类 号：R735.7[医药卫生—肿瘤]