Unorthodox chemistry for an unorthodox challenge:Exploration of new chemical reactivities for a sustainable future  

作　　者：LI Chao-Jun 

机构地区：[1]Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 2K6, Canada

出　　处：《Science China Chemistry》2011年第12期1815-1830,共16页中国科学（化学英文版）

基　　金：the Canada Research Chair (Tier I) foundation;the E. B. Eddy Endowment Fund;the CFI, NSERC, FQRNT;the NSF and the NSF-EPA Joint Program for a Sustainable Environment for partial support of our research over the years

摘　　要：The sustainable development of our future represents an unorthodox challenge in sciences and technologies.The exploration of unconventional chemical reactivities that could potentially result in more sustainable chemical productions with efficient utilization of resource and inherent prevention of waste will provide the foundation for the synthetic chemistry of our future.As part of this endeavor,we have explored metal-mediated reactions in water to minimize protection-deprotection and the use of organic solvents,catalytic nucleophilic additions via C-H reactions to avoid generation and use of stoichiometric organic halides and metal in water,and Cross-Dehydrogenative-Coupling(CDC) reactions to minimize overall transformation steps.The sustainable development of our future represents an unorthodox challenge in sciences and technologies. The exploration of unconventional chemical reactivities that could potentially result in more sustainable chemical productions with efficient utilization of resource and inherent prevention of waste will provide the foundation for the synthetic chemistry of our future. As part of this endeavor, we have explored metal-mediated reactions in water to minimize protection-deprotection and the use of organic solvents, catalytic nucleophilic additions via C-H reactions to avoid generation and use of stoichiometric organic halides and metal in water, and Cross-Dehydrogenative-Coupling （CDC） reactions to minimize overall transformation steps.

关 键 词：green chemistry organometallic reactions in water aldehyde-alkyne-amine coupling cross-dehydrogenative-coupling 

分 类 号：TQ465[化学工程—制药化工] X22[环境科学与工程—环境科学]