缺血性脑血管病患者颈动脉粥样硬化程度与循环内皮祖细胞的相关性分析  

Correlation analysis of carotid atherosclerosis degree and the number of circulation endothelial progenitor cells in ischemic cerebrovascular disease patients

作　　者：屈新辉[1] 王卫真[2] 蒋婷[2] 何丹[3] 谢旭芳[1] 吴晓牧[1] 张昆南[1] 

机构地区：[1]江西省人民医院神经内科,南昌330006 [2]江西省人民医院超声诊断科,南昌330006 [3]江西省人民医院中心实验室,南昌330006

出　　处：《中国实用神经疾病杂志》2011年第24期15-17,共3页Chinese Journal of Practical Nervous Diseases

基　　金：十一五国家科技支撑计划资助项目(2008BAI68B03)

摘　　要：目的探讨缺血性脑血管病患者颈动脉粥样硬化程度与循环内皮祖细胞(EPCs)的相关性。方法根据CD133和KDR标记,采用流式细胞仪检测缺血性脑血管病患者(包括TIA、急性脑梗死、颈动脉粥样硬化)和健康体检者外周血内皮祖细胞(EPCs)数量变化。结果缺血性脑血管病患者EPCs数量较对照组明显减少(P<0.01);随着颈动脉粥样硬化程度加重,EPCs数量呈降低趋势,颈动脉重度狭窄与轻度和中度狭窄相比有差异(P<0.05);急性脑梗死和TIA患者较单纯颈动脉粥样硬化患者EPCs数量明显增加(P<0.01)。结论缺血性脑血管病患者EPCs与颈动脉粥样硬化程度呈负相关,可反映颈动脉粥样硬化的程度;急性缺血可能会增加EPCs的动员。Objective To analyze the correlation between the number of peripheral blood endothelial progenitor cells （EPCs） and carotid atherosclerosis degree in ischemic cerebrovascular disease patients. Methods The number of peripheral blood EPCs of ischemic cerebrovascular disease patients （including TIA, acute cerebral infarction and carotid atherosclerosis） and health control people were detected by flow cytometry. The cells were marked by CD133 and KDR. Results Compared with control group, the number of EPCs of ischemic cerebrovascular disease group was decreased significantly （P（0.01）. Accompany with carotid artery stenosis was aggravated, the number of EPCs presented decreasing. In comparison with light carotid artery stenosis group and middle carotid artery stenosis group, the number of EPCs of serious carotid artery stenosis group was increased （P〈0.05）. Compared with single carotid atherosclerosis patients, the numbers of EPCs of TIA patients and acute cerebral infarction patients were increased significantly （P〈0.01）. Conclusion The degree of carotid artery stenosis has negative correlation with the number of EPCs in ischemic cerebrovascular disease patients. It is indicated the degree of carotid artery stenosis. EPCs mobilization are possibly increased by acute ischemia.

关 键 词：缺血性脑血管病 脑梗死 TIA 颈动脉粥样硬化 颈动脉狭窄 内皮祖细胞(EPCs) 

分 类 号：R743.31[医药卫生—神经病学与精神病学]