妇科晚期恶性肿瘤术中腹腔灌注化疗临床疗效分析  

The Analysis of Effect of Intraperitoneal Chemotherapy in the Treatment of Advanced Gynecological Malignancies

作　　者：王云燕 杨琦 

机构地区：[1]镇平县人民医院妇产科,河南镇平474250

出　　处：《肿瘤基础与临床》2011年第6期510-512,共3页journal of basic and clinical oncology

摘　　要：目的探讨妇科晚期恶性肿瘤术中行腹腔灌注化疗的疗效。方法 169例妇科晚期恶性肿瘤随机分为两组,试验组86例分别用顺铂或卡铂、阿霉素、环磷酰胺稀释后腹腔内灌注化疗;对照组83例采用PC、PAC方案常规静脉化疗,比较观察两组的疗效和毒副反应。结果试验组和对照组在手术时间、切口愈合情况、术后感染、毒副反应及术后肝肾功能等方面比较差异无统计学意义(P>0.05);术后同期CEA、CA125,试验组较对照组明显降低(P<0.05);术后腹水引出量试验组明显少于对照组(P<0.05)。结论妇科晚期恶性肿瘤患者行术中腹腔灌注化疗安全、有效,并能有效控制腹水,优于静脉化疗。Objective To investigate the effect of intraperitoneal chemotherapy in the treatment of advanced gynecological malignancies. Methods All the 169 cases of advanced gynecological malignancies were randomly divided into two groups. The 86 cases in the test group received intraperitoneal chemotherapy with eisplatin or carboplatin, doxorubicin, cyclophosphamide;the 83 cases in the control group received PC or PAC regimen chemotherapy. The effect and toxicities of the two groups were evaluated comparatively. Results The operative time, wound healing, postoperative infection, toxicities and postoperative liver and kidney function had no significant differences in the test group and the control group （P 〉 0.05 ） ;the postoperative CEA, CA125 in the test group were significantly lower than those in the control group （P 〈 0.05 ） ; the postoperative ascites amount in the test group was significantly lower than that in the control group （ P 〈 0.05 ）. Conclusion Intraperitoneal chemotherapy is effective and safe in the treatment of advanced gynecological malignancies, it can effectively reduce ascites, and it is better than intravenous chemotherapy.

关 键 词：腹腔灌注化疗 女性生殖系统 妇科恶性肿瘤 

分 类 号：R737.3[医药卫生—肿瘤] R730.58[医药卫生—临床医学]