全新视角透视口腔黏膜组织工程  

New perspectives of oral mucosa engineering

作　　者：陈洁[1] 陈莉莉[1] 刘加荣[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院口腔科,武汉430022

出　　处：《国际口腔医学杂志》2012年第1期59-62,共4页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(30970740);湖北省卫生厅科研基金资助项目(JX4B10)

摘　　要：口腔黏膜组织工程主要应用于修复因肿瘤切除、牙周病、外伤等导致的软组织缺损。以前的组织工程研究主要围绕上皮细胞培养方法的发展以及结缔组织支架材料的研发开展,本文将对口腔黏膜组织工程替代物的培养模式、支架结构、基质功能及临床应用进行综述,展示组织工程的新视角及口腔黏膜组织工程的新应用。Tissue-engineered oral mucosal equivalents have been developed for clinical applications, such as restore the soft tissue defects due to excision of tumor, parodontopathy, trauma and so on. In the last several decades, researches have mainly concentrated on the development of epithelial cell culture methods and introducing new dermal scaffolds. In this review we will focus on the oral mucosa equivalent reconstructed models, the scaffold, the important role of the extracellular matrix, and display the new concept of tissue engineering and the new application of oral mucosa tissue engineering.

关 键 词：口腔黏膜 组织工程 新视角 

分 类 号：R78[医药卫生—口腔医学]