局部亚低温对脑出血后血清MMP-9和c-Fn的影响  

The impact of local mild hypothermia on serum levels of serum matrix metalloproteinase (MMP-9) and cell fibronectin (c-Fn) in patients with intracerebral hemorrhage

作　　者：甄云[1] 陈天宝[1] 陈麒声[1] 胡少杰[1] 黄振林[1] 

机构地区：[1]广东医学院附属深圳西乡人民医院神经外科,广东深圳518102

出　　处：《中国热带医学》2011年第11期1402-1403,共2页China Tropical Medicine

摘　　要：目的研究局部亚低温治疗对急性脑出血患者血清基质金属蛋白酶(MMP-9)和细胞纤维连接蛋白(cellularfib ronectin,c-Fn)的影响。方法随机将80例脑出血患者分为局部亚低温组(40例)和常规治疗组(40例),同时设健康对照组23例;常规治疗组应用药物治疗,局部亚低温组在药物治疗基础上加用局部亚低温治疗,观察两组患者发病第1、3、7d血清MMP-9和c-Fn水平的变化。结果两组患者发病第1d血清MMP-9和c-Fn水平均高于健康对照组(P<0.01);第3d常规治疗组MMP-9和c-Fn水平达高峰,局部亚低温组下降,明显低于常规治疗组(P<0.05);在发病第7d,局部亚低温组血清MMP-9和c-Fn仍明显低于常规治疗组(P<0.05)。结论颅脑局部亚低温治疗可显著降低脑出血后患者血清MMP-9和c-Fn的浓度,减轻脑出血后的炎症反应,发挥其脑保护作用。Objective To study the impact of local mild hypothermia on serum serum matrix metalloproteinase（MMP-9） and cell fibronectin（c-Fn） in patients with acute intracerebral hemorrage.Methods Eighty patients with acute cerebral hemorrage were randomly divided into local mild hypothermia group（40 cases） and routine therapy group（40 cases）.Meanwhile,there was a control group of twenty-three healthy cases.Conventional drugs were given to routine therapy group while the mild hypothermia group was given local mild hypothermia treatment but for conventional therapy.Serum levels of MMP-9 and c-Fn in patients were determined dynamically on the 1st,3rd and 7th day after paroxysm.Results On the 1st day after paroxysm,the serum levels of MMP-9 and c-Fn in patients with intracerebral hemorrhage were apparently higher than the normal controls（P0.01）.On the 3rd day,the levels of MMP-9 and c-Fn were significantly decreased in local mild hypothermia group in comparison with routine therapy group（P0.05）.On the 7th day after paroxysm,the levels of MMP-9 and c-Fn in local mild hypothermia group were still significantly lower than that of routine therapy group（P0.05）.Conclusion The local mild hypothermia therapy can not only dramatically reduce the serum levels of MMP-9 and c-Fn but also inhibit inflammatory reaction so as to protect neurological function in patients with cerebral hemorrhage.

关 键 词：局部亚低温 脑出血 血清基质金属蛋白酶(MMP-9) 细胞纤维连接蛋白(c-Fn) 

分 类 号：R743.34[医药卫生—神经病学与精神病学]