胰腺浸润性导管癌c-kit蛋白表达的临床意义  

Clinical Significance of c-kit Protein Expression in Invasive Ductal Carcinoma of the Pancreas

作　　者：马晋峰[1] 郗彦凤[1] 崔慧林[2] 

机构地区：[1]山西省肿瘤医院,山西太原030013 [2]山西医科大学,山西太原030001

出　　处：《山西职工医学院学报》2011年第4期7-9,共3页Journal of Shanxi Medical College for Continuing Education

摘　　要：目的:研究c-kit蛋白在胰腺浸润性导管癌的表达及其临床病理意义。方法:采用免疫组织化学法显示c-kit蛋白在正常胰腺和胰腺浸润性导管癌组织中的表达,计算免疫反应计分(immunoreactive score,IRS),并统计分析c-kit蛋白阳性表达与临床病理因素的相关性。结果:c-kit蛋白主要表达在胰腺导管细胞和腺泡细胞的胞质,在胰腺浸润性导管癌细胞中的免疫反应计分值明显高于正常导管细胞,阳性表达率为74.5%。c-kit蛋白表达与肿瘤大小和分化类型有相关性,但与临床分期、淋巴结转移等无相关性(P>0.05)。结论:c-kit蛋白在胰腺癌肿瘤形成过程中可能起重要作用,临床检测c-kit有利于胰腺癌的病理诊断和指导靶向药物治疗。Objective ：To explore the expression of c-kit protein and its clinicopathologic significance in invasive ductal carcinoma （IDC） of the pancreas. Methods： The immunohistochemical method was adopted to get the expression of c-kit protein in normal pancreatic tissues and IDC cells, where the immunoreactive score （IRS） of c-kit protein expression was examined. Relevance between c-kit positive expression and clinicopathological factors was analyzed statistically. Result： The IRS values of c-kit protein expression in IDC cells were significantly higher than those in normal ductal cells. The positive expression rate was 74.5 %. c-kit protein expression was correlated with the tumor size and the differentiated degree in patients with c-kit-positive pancreatic cancer, but not with the clinical staging or lymph-node me- tastasis （P 〉 0.05）. Conclusions： c-kit protein may play an important role in the neoplasia of pancreatic neoplasms. The clinical examination of c-kit protein is useful for clinic diagnosis and target medication.

关 键 词：c—kit蛋白 免疫反应计分 胰腺浸润性导管癌 

分 类 号：R735.9[医药卫生—肿瘤]