乳腺鳞状细胞癌临床病理分析  

作　　者：王纯[1] 袁静萍[2] 袁修学[3] 杨月红[2] 罗波[2] 向春香[2] 

机构地区：[1]武汉市中心医院肿瘤科,武汉430014 [2]武汉市中心医院病理科,武汉430014 [3]武汉科技大学医学院

出　　处：《中华内分泌外科杂志》2011年第6期383-386,共4页Chinese Journal of Endocrine Surgery

基　　金：胡北省武汉市卫生局立项课题（2006008）

摘　　要：目的探讨乳腺鳞状细胞癌（SCC）的临床病理和免疫组化特征。方法分析3例乳腺SCC临床资料，观察其组织学形态和免疫表型，并复习相关文献。结果3例乳腺SCC均为女性，平均年龄43岁，肿瘤平均直径4．3cm，淋巴结转移1例；2例表现为无痛性肿块，1例伴局部皮肤红肿疼痛及溃疡。镜下表现：癌巢由多边形或梭形细胞构成，细胞质红染，可见明显角化珠和细胞间桥。间质纤维化，伴玻璃样变，肿瘤周边见淋巴细胞浸润。免疫组化染色显示ER、PR、HER．2、CKl8、SMA均阴性，CK、CKl4、CK5／6、p63、S-100和vimentin均阳性。结论乳腺SCC是一种罕见而形态独特的乳腺癌亚型。呈基底细胞样免疫表型，预后差，是基底细胞样型乳腺癌的典型代表。Objective To study the clinicopathological and immunohistochemical features of squamous cell carcinoma (SCC) of breast.Methods Three cases with breast SCC were studied by analyzing their clinical data,histomorphology and immunophenotype.The related literature was reviewed.Results The patients were all females.Their ages ranged from 37 to 50 years,with 43 years as the medium.The tumor diameter was 2-9 cm,with 4.3 cm as the medium.Metastasis of axillary lymph node was found in one case,accounting for 33％ of the total.Two cases had painless lumps in their left breasts.One case had a lump with local inflammation,pain and ulcer in her left breast.Histopathological examination showed the polygonal and spindle-shaped cells with eosinophilic cytoplasm were found in cancer nest,as well as the prominent intercellular bridges and keratin pearls were found to be rich in three cases.Interstitial fibrosis with hyalinization and lymphocytic infiltrate around the tumor was also found.Immunohistochemistry showed ER,PR,HER-2,CK18 and SMA were negative while CK,CK14,CK5/6,p63,S-100 and vimentin were positive.Conclusions SCC is a rare subtype of breast carcinoma with distinct histopathological and morphological features.SCC is a typical basal-like breast carcinoma,and the majority of breast SCC appear a basal-like immunophenotype with poor prognosis.

关 键 词：乳腺 鳞状细胞癌 免疫表型 

分 类 号：R737.9[医药卫生—肿瘤]