针刺太溪穴和非穴对轻度认知障碍功能性磁共振成像的影响  

Effect of Needling Taixi(KI3)Acupoint and Sham Point on Functional Magnetic Resonance Imaging in Mild Cognitive Impairment Patients

作　　者：蒋垂刚[1] 崔韶阳[1] 聂彬彬[2] 唐纯志[3] 张家维[3] 

机构地区：[1]广州中医药大学 [2]中国科学院高能物理研究所中国科学院核分析技术重点实验室,北京100049 [3]广州中医药大学针灸推拿学院,广东广州510405

出　　处：《新中医》2012年第1期93-95,共3页New Chinese Medicine

摘　　要：目的:运用fMRI技术观察针刺轻度认知障碍(MC)I患者右侧太溪穴和非穴时不同脑区的激活情况,比较针刺太溪穴与非穴的不同。方法:将24例MCI患者,随机分为太溪穴组和非穴组,分别给予针刺右侧太溪穴和非穴;实验采用单组块设计,分为针刺前静息态、捻针状态及出针后3个模块。扫描后图像使用SPM2进行后处理。结果:针刺太溪穴激活右侧扣带回BA24、双侧额内侧回BA6、左侧中央后回BA3。针刺非穴激活左侧中央后回BA2、左侧顶下小叶BA40、左小脑。结论:与针刺非穴比较,针刺太溪穴靶向性激活了MCI患者病变脑区,且对相关脑区具有整体性调节效应。Objective. To observe the effect of needling Taixi （KI3） and sham point on the activation of various encephalic region in patients with mild cognitive impairment（MCI）by functional magnetic resonance imaging （fMRI） technique. Methods. Twenty-four patients with MCI were randomly divided into KI3 group and sham point group. The patients received needling right lateral Taixi （KI3） or sham point according to the experimental method. We applied a block design, which included three blocks, resting state, rotating state and needle-withdrawing state. Scanned images were analyzed by SPM2. Results： Right cingulate gyrus（BA24）, bilateral medial frontal gyrus（BA6）, and left postcentral gyrus（BA3）were evoked after needling Taixi（KI3）. Left postcentral gyrus （BA2）, left inferior parietal Iobule （BA40）, and left cerebellum were evoked after needling sham point. Conclusion. Compared with needling sham point, needling Taixi（KI3） can activate the target-based encephalic region of MCI patients, and has integral adjustment on related encephalic region.

关 键 词：轻度认知障碍 针刺 太溪 非穴 磁共振成像 

分 类 号：R742[医药卫生—神经病学与精神病学]