抽动障碍患儿432例血铅水平对脑电图活动的影响  

Influence of Blood Lead Level on Electrical Activity of Brain in 432 Children with Tic Disorder

作　　者：田广燕[1] 梁向荣[1] 高在芬[1] 刘勇 

机构地区：[1]山东大学齐鲁儿童医院神经科,济南250022

出　　处：《实用儿科临床杂志》2011年第24期1860-1861,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨抽动障碍患儿血铅水平变化对脑电活动的影响及其发病机制的研究,对比不同血铅水平患儿脑电图变化的特点。方法对本院2005年1月-2011年4月临床确诊的432例抽动障碍患儿进行血铅水平及脑电图检测。采用原子吸收光谱分析法测定其血铅水平,并进行t检验。将432例抽动障碍患儿分为3组,Ⅰ组:血铅水平<50μg.L-1;Ⅱ组:血铅水平50～100μg.L-1;Ⅲ组:血铅水平>100μg.L-1。结果 1.Ⅰ组患儿脑电图异常发生率为7.14%(2/28例),Ⅱ组患儿脑电图异常发生率为14.23%(40/281例),Ⅲ组患儿脑电图异常发生率为46.34%(57/123例)。Ⅰ组与Ⅱ组脑电图异常发生率比较差异无统计学意义(P>0.05),Ⅰ组与Ⅲ组脑电图异常发生率比较差异有统计学意义(P<0.01),Ⅱ组与Ⅲ组脑电图异常发生率比较差异有统计学意义(P<0.01)。2.除年龄≤4岁患儿外,脑电图异常患儿较脑电图正常患儿血铅水平明显升高(P<0.01,0.05)。结论血铅水平升高会加重抽动障碍患儿的脑功能损伤。及早进行驱铅治疗可能对抽动障碍患儿脑功能损伤的恢复有重要意义。Objective To study the influence and pathogenesis of blood lead level on electrical activity of brain in children with tic disorder, and to research the characteristics of electroencephalogram （EEG） in children with different concentrations of blood lead. Methods The level of blood lead and EEG were assessed in 432 children with tic disorder from Jan. 2005 to Apr. 2011. The level of blood lead were examined by atomic absorption spectrophotometry method. Statistical analysis were performed by t - test. According to the blood lead level, the children were divided into 3 groups, group Ⅰ ：blood lead 〈50μg· L-1 ,group Ⅱ ：50 - 100μg·L-1 ,group Ⅲ ： 〉 100μg ·L-1 Results 1. The EEG abnormal statistics results showed abnormal rate in group Ⅰ ,group Ⅱ and group Ⅲ were 7.14% （2/28 cases）, 14.23% （40/ 281 cases） and 46.34% （57/123 cases）, respectively. There was no significant difference in blood lead level of children with abnormal EEG between group Ⅰ and group Ⅱ （ P 〉 0.05 ）. There were significant differences between group Ⅰ and group Ⅲ （ P 〈 0. 01 ）, and between groupⅡ and groupⅢ （ P 〈 0. 01 ）. 2. The children with tic disorder showed abnormal EEG had obviously higher level of blood lead than those with tic disorder showed normal EEG, two groups had significant differences （P 〈 0.01,0.05 ）. Conclusions The brain damage of children with tic disorder become more serious as the level of blood lead increases. Timely chelating treatment had important clinical significance to brain damage recovering of children with tic disorder.

关 键 词：血铅 抽动障碍 脑电图 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]