GSTM_1、GSTT_1基因多态性与家族聚集性肝癌的遗传易感性研究  

Gene polymorphisms of GSTM_1 and GSTT_1 in the clustering families of hepatocellular carcinoma

作　　者：肖开银[1] 黎乐群[1] 彭民浩[1] 覃晓[1] 彭涛[1] 郭雅[1] 陈滨[1] 卢景宁[1] 秦权林[1] 桂文波[1] 

机构地区：[1]广西医科大学第一附属医院肝胆外科,南宁530021

出　　处：《中国癌症防治杂志》2011年第4期287-290,共4页CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT

基　　金：广西自然科学基金资助项目(桂科自0728145)

摘　　要：目的探讨GSTM1、GSTT1基因多态性与家族聚集性肝癌遗传易感性的关系。方法应用PCR技术检测GSTM1、GSTT1在家族聚集性肝癌和肝癌高发家系的基因表型。结果家族聚集性肝癌组GSTM1(-)、GSTT1(-)基因型频率分别为68.8%、47.5%,显著高于非家族聚集性肝癌组(54.6%、30.8%)和对照肝组织组(53.3%、25.3%)(P<0.05);随着家族中患肝癌病例数的增加,GSTM1(-)、GSTT1(-)基因型的频率逐渐升高,肝癌高发家系组GSTM1(-)、GSTT1(-)基因型频率分别为68.1%和44.9%,显著高于对照家系组(47.5%、25.0%)(P<0.05)。若将GSTM1(-)T1(-)基因型视为危险暴露因素,家族聚集性肝癌组GSTM1(+)T1(+)和GSTM1(+)T1(-)/GSTM1(-)T1(+)基因型频率均显著低于非家族聚集性肝癌组和对照肝组织组(P<0.01)。结论 GSTM1、GSTT1遗传多态性与家族聚集性肝癌的遗传易感性有关,GSTM1(-)、GSTT1(-)基因型可能是肝癌家族成员的危险暴露因素。Objective To investigate the relationship between gene polymorphisms of glutathione-S-transferase Mj （GSTM1） and Tl （GSTT1） and hepatocellular carcinoma （HCC）-clustering family. Methods the genotype of GSTM1 and GsTrl in the HCC-clustering family and high-incidence pedigrees of HCC were detected with PCR. Results The frequencies of GSTMI null and GsTrl null genotype were 68.8% and 47.5% in the group of HCC-clustering family respectively, which were significantly higher than those of the none-clustering HCC family （54. 6% and 30. 8% ） and control group （53.3% and 25. 3% ）. The same tendency was also found between high-incidence pedigrees of HCC and control pedigrees. With the increasing number of HCC patient in familial history, the frequencies of GSTM1 null and GSTT1 null genotype increased too. The risk of HCC increased with the GSTM） null genotype combined GsTrl null genotype. Conclusion Gene polymorphisms of GSTM1 and GsTr） are asso- ciated with the susceptibility of HCC-clustering family. GSTM1 null genotype and GSTT1 null genotype are the risk factors in HCC-clustering family.

关 键 词：肝肿瘤 家族聚集性 遗传易感性 基因多态性 谷胱甘肽S转移酶 

分 类 号：R735.7[医药卫生—肿瘤]