原发性高血压患者动脉僵硬度与Th17细胞相关效应因子的关系  

Correlation Between Arterial Stiffness and Th17-Associated Cytokines in Essential Hypertensive Patients

作　　者：刘振东[1] 路方红[1] 赵颖馨[1] 孙尚文[1] 王舒健[1] 胡小亮[1] 李俊[1] 

机构地区：[1]山东省医学科学院基础医学研究所心脑血管病防治研究中心,山东省济南市250062

出　　处：《中国动脉硬化杂志》2012年第1期57-60,共4页Chinese Journal of Arteriosclerosis

基　　金：山东省自然科学基金项目(ZR2009CL029);山东省医药卫生计划项目(2009HW080);山东省医学科学院项目(2009-16;2009-17;2010-13)

摘　　要：目的探讨原发性高血压患者动脉僵硬度与Th17细胞相关效应因子白细胞介素17、白细胞介素6及肿瘤坏死因子α的相关性。方法测定入选的280例原发性高血压患者肱踝脉搏波传导速度(baPWV),根据测定的baPWV值的四分位数,将高血压患者分为4组,即baPWV<1444 cm/s组、1444 cm/s≤baPWV<1767 cm/s组、1767 cm/s≤baPWV<2169 cm/s组和baPWV≥2169 cm/s组。检测所有入选患者的血清白细胞介素17、白细胞介素6及肿瘤坏死因子α水平。结果高baPWV值组患者的血清白细胞介素17、白细胞介素6及肿瘤坏死因子α水平较低baPWV值组患者升高,四组分别进行两两比较,差异均有统计学意义(P<0.05)。Pearson相关分析及多元线性逐步回归分析显示,baPWV与白细胞介素17、白细胞介素6及肿瘤坏死因子α均呈正相关(r分别为0.565、0.556及0.447,P均<0.001),白细胞介素17、白细胞介素6及肿瘤坏死因子α是影响baPWV的主要因素。结论原发性高血压患者动脉僵硬度与Th17细胞相关效应因子的血清水平相关。Aim To explore the association between arterial stiffness and related cytokines of Thl7 cell in essen- tial hypertension. Methods Brachial ankle pulse wave velocity （baPWV） was observed in 280 essential hypertensive patients. According to the quartile of tested baPWV value all patients were divided into four groups, namely, baPWV 〈 1444 cm/s group, 1444 cm/s≤baPWV 〈 1767 cm/s group,1767 cm/s≤baPWV 〈2169 cm/s group and baPWV≥2169 cm/ s group. Serum levels of interleukin （IL）-17,IL-6 and tumor necrosis factor （TNF）-α were tested in all hypertensive pa- tients. Results The levels of serum IL-17, IL-6 and TNF-α were elevated in higher level of baPWV groups than that in lower level of baPWV group. The results of independent-samples T test in the level of serum IL-17, IL-6 and TNF-α showed that there were significant differences in every two groups, respectively （ P 〈 0. 05 ）. BaPWV was positively correlated with IL-17, IL-6 and TNF-α（r = 0.565, 0.556 and 0.447, P 〈0.001）, respectively. Multiple linear regression analysis showed that IL-17, IL-6 and TNF-α were risk factors of baPWV. Conclusion The related cytokines of Th17 cell were associated with arterial stiffness in essential hypertensive patients.

关 键 词：高血压 脉搏波传导速度 TH17细胞 细胞因子 

分 类 号：R363[医药卫生—病理学]