诱导升压介入时间对大鼠局灶型脑缺血的影响  

Effects of different beginning time of induced hypertension on experimental focal cerebral ischemia

作　　者：张合亮[1] 马廉亭[1] 刘美利[2] 

机构地区：[1]南方医科大学附属广州军区武汉总医院神经外科,武汉市430070 [2]天津泰达医院神经科,300457

出　　处：《实用医学杂志》2011年第24期4380-4382,共3页The Journal of Practical Medicine

摘　　要：目的:探讨实验性脑缺血后诱导升压介入早晚对其疗效的影响。方法:通过线栓法制作大鼠大脑中动脉梗死模型,随机分为A组(梗死30 min后行苯肾上腺素升压治疗),B组(60 min后升压),C组(90min后升压),D组(120 min后升压)和E组(对照组,无升压)。缺血2.5 h后再通闭塞动脉,应用激光多普勒血流仪记录缺血区血流变化,再灌注24 h后评定梗死体积。结果:诱导升压可显著提高缺血区血流灌注(A、B、C和D组均高于E组,P均<0.05),减小脑梗死体积(A、B、C和D组均小于E组,P均<0.05);而且梗死后,诱导升压开始时间越早,效果越明显(脑血流,A组优于D组,P<0.05;脑梗死体积,A组小于C组和D组,C组小于D组,P均<0.05)。结论:大鼠大脑中动脉急性闭死后,采用苯肾上腺素升压可显著改善缺血区血流灌注,降低脑梗死体积,且诱导升压开始时间越早,效果越明显。Objective To investigate the effects of different beginning time of induced hypertension on experimental focal cerebral ischemia. Methods A total of 30 Sprague-Dawley rats who suffered 2.5 h middle cerebral occlusion were randomly divided into 5 groups： Group A （treated with phenylephrine after 30 min of middle cerebral artery occlusion）, Group B （after 60 min）, Group C （after 90 rain）, Group D （after 120 min）, and Group E （control group, no phenylephrine was used）. Changes of cerebral blood flow were recorded by laser Doppler flowmetry, and the volume of cerebral infarction 24 h after reperfusion was evaluated. Results The cerebral blood flow in Group A, B, C, and D were significantly improved （all P 〈 0.05） and the volume of cerebral infarction in these 4 groups were obviously decreased （all P 〈 0.05） as compared with those in Group E. In addition, cerebral blood flow in Group A was better than that in Group D （P 〈 0.05）, the volume of cerebral infarction was less in Group A than those in Group C and D, and also was less in Group C than that in Group D （all P 〈 0.05）. Conclusion Induced hypertension by phenylephrine before reperfusion is an effective strategy for treating focal cerebral ischemia in rats, and the earlier induced hypertension begins the better effectiveness it has.

关 键 词：脑缺血 诱导升压 苯肾上腺素 脑血流 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]