康成贴膏对昆明小鼠镇痛作用的实验研究  

Experimental Studies on Analgesic Effect of Kang-cheng Tiegao

作　　者：潘坚[1] 王禹斌[2] 周慧英[2] 王婧[2] 周正宇[2] 黄猛[2] 薛智谋[2] 

机构地区：[1]苏州大学实验材料供应中心,江苏苏州215123 [2]苏州大学医学部,江苏苏州215123

出　　处：《中国医药指南》2011年第36期252-254,共3页Guide of China Medicine

基　　金：江苏省自然科学基金(L221603710)

摘　　要：目的观察康成贴膏镇痛活血化淤作用,为临床应用提供一定的实验依据。方法昆明小鼠分为五组,即空白组,低、中、高剂量组,阳性对照组,于后肢脱毛处敷贴药膏,通过扭体法实验测定疼痛抑制率,通过热板法实验测定给药4天后痛阈值。结果康成贴膏可明显抑制冰乙酸所致扭体反应次数,提高痛觉抑制率,与空白相比,差异显著(P<0.01);可延长小鼠热板反应潜伏期,提高疼痛反应阈值,给药4d后的180min,各剂量组小鼠痛阈均明显提高(P<0.01);结论康成贴膏有明显抑制疼痛和活血化淤作用。Objective In order to observe the analgesic effect of Kang-cheng tiegao （KCTG） and provide medical basis for its clinic use. Methods Mice were randomly divided into 5 groups： negative control group, low-dose group, medium- dose group, high-dose group and positive control group. The inhibitory rate of sensation of pain was observed by Mice hot plate test and the latent period was investigated by writhing reflex test. Results Kang-cheng tigao could significantly restrain the writhing reflex caused by acetic acid and enhance inhibitory rate of sensation of pain （P〈0.01） ; The latent period in mice hot plate analysis was prolonged. Less blood spots area and shorter recovery time after administration. Conclusions The results showed Kang-cheng tiegao has significant analgesic effect.

关 键 词：康成贴膏 镇痛作用 热板法 扭体法 

分 类 号：R914.1[医药卫生—药物化学]