维他通软胶囊对血脂水平调节作用的实验研究  

Experimental Study of WeiTaTong Soft Capsules on Adjusting Serum Lipid Levels

作　　者：孙丽枫[1] 吴红彦[2] 王虎平[2] 

机构地区：[1]兰州市疾病预防控制中心,甘肃兰州730030 [2]甘肃中医学院

出　　处：《西部中医药》2011年第12期17-18,共2页Western Journal of Traditional Chinese Medicine

摘　　要：目的:观察维他通软胶囊对大鼠血脂水平的调节作用。方法:喂饲高脂饲料复制高脂大鼠模型并以维他通软胶囊分低、中、高剂量组进行对抗防治,30天后测定大鼠血清总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)含量。结果:维他通软胶囊各剂量组与高脂对照组给药前的血清TC,TG,HDL-C水平无显著性差异(P>0.05);给药30天后,维他通软胶囊低、中剂量组大鼠的血清TC,TG含量与高脂对照组比较,无显著性差异(P>0.05);维他通软胶囊高剂量组组大鼠的血清TC,TG含量与高脂对照组相比,有显著性差异(P<0.05)。各组大鼠实验前的血HDL-C水平无明显差异(P>0.05);给药30天后HDL-C水平亦无显著性差异(P>0.05)。维他通软胶囊低、中、高剂量组分别可使大鼠血清TC水平分别下降10.2%、12.7%和18.3%;TG水平分别下降23.9%、16.7%和23.9%;低剂量组HDL-C水平下降2.3%,中、高剂量组HDL-C水平分别上升9.3%和2.3%。结论:维他通软胶囊有较好的降血脂作用。Objective：To study the influence of WeiTaTong soft capsules on serum lipid of model rats with hyperlipidemia to explore the adjustment of WeiTaTong soft capsules.Method：The model rats with hyperlipidemia induced by high fat diet were fed with WeiTaTong soft capsules at the low,moderate,high dose for 30 days.The contents of TC,TG and HDL-C of the rats were detected to statistically analyze the adjustment of WeiTaTong soft capsules.Result：Comparison of the levels of TC,TG,HDL-C before medication among different doses of WeiTaTong soft capsules groups and hyperlipidemia control group showed no significant difference（P0.05）;After medication for 30 days,comparison of the contents of TC and TG among the low-dose,moderate-dose WeiTaTong group and hyperlipidemia control group indicated no significant differences（P0.05）,while comparison of the contents of TC and TG between high-dose WeiTaTong group and hyperlipidemia control group showed a significant difference（P0.05）.Comparison of HDL-C content among different groups showed no significant difference（P0.05）before or after the experiments.TC of low,moderate,high dose WeiTaTong groups were decreased by 10.2%,12.7% and 18.3% respectively;TG were decreased by23.9%,16.7% and 23.9%;while HDL-C of low-dose group decreased by 2.3%,HDL-C moderate-dose and high-dose group were increased by 9.3% and 2.3%.Conclusion：WeiTaTong soft capsules can effectively lower serum lipid.

关 键 词：血脂 维他通软胶囊 大鼠 动物实验 

分 类 号：R743.3[医药卫生—神经病学与精神病学]