双歧醋对高脂饮食大鼠血脂的影响  

The influence of bifidobacterium vinegar on the plasama lipid of rat fed with high-fat diet

作　　者：李金玲[1] 张德纯[1] 王春耀[1] 郭亚楠[1] 

机构地区：[1]重庆医科大学病原生物学教研室分子医学与肿瘤研究中心,重庆400016

出　　处：《中国微生态学杂志》2011年第12期1084-1086,1090,共4页Chinese Journal of Microecology

摘　　要：目的探讨双歧醋对高脂饮食大鼠血脂的影响作用。方法 48只SD大鼠被随机分成双歧醋低剂量组[1.8 mL/(kg.BW)]、中剂量组[3.4 mL/(kg.BW)]、高剂量组[6.8 mL/(kg.BW)]和市售醋组[3.4 mL/(kg.BW)]、高脂模型组以及正常组,观察双歧醋对高脂饮食大鼠血脂的影响作用,测定指标包括大鼠体重、肝指数、体脂指数、病理学观察肝脏脂肪变性等。结果实验结果显示,双歧醋各组所有测定指标值都较高脂模型组有明显好转,特别是甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)水平双歧杆菌醋的高、中量组与市售醋组比较差异有统计学意义(P<0.05)。结论双歧醋能有效预防高脂饮食大鼠的血脂水平升高,对预防体重、肝指数升高和肝脏脂肪变性也有一定作用。Objective To discuss the prophylactic antiobesity effect of bifidobacterium vinegar and possible mechanism. Method 48 SD rats were randomly divided into 6 groups ： bifidobacterium vinegar groups of three different doses, ordinary vineger group, high-fat model group and basic group. The effect of bifidobacterium vinegar on rats fed with high-fat diet was observed. Body weight, body fat index, fatty degeneration in liver were determined. Result All indicator values measured were improved obviously compared with high-fat model group. Particularly, TCHO, HDL-C levels of high and medium dosage bifidobacterium vinegar groups were improved obviously compared with ordinary vineger group. Conclusion Bifidobacterium vinegar can prevent rats fed with high-fat diet from development of high TG and HDL-C, and prevent the body weight, liver index, fatty degeneration in liver from increasing in some degree.

关 键 词：双歧醋 大鼠 胆固醇 高脂血症 

分 类 号：R378.992[医药卫生—病原生物学]