诱发性胸腺淋巴瘤动物模型的建立  

Establishment of Induced Animal Model with Thymic Lymphoma

作　　者：王洪艳[1,2] 徐彩云[3] 宋祥福[1] 龚守良[1] 

机构地区：[1]吉林大学公共卫生学院卫生部放射生物学重点实验室,长春130021 [2]北华大学公共卫生学院,长春132001 [3]吉林大学白求恩医学院动物实验中心,长春130021

出　　处：《实验动物与比较医学》2011年第6期478-482,共5页Laboratory Animal and Comparative Medicine

摘　　要：胸腺瘤是最常见的纵隔肿瘤,其病因学和发病机制尚不清楚.合适的动物模型是研究该病病因学、发病机制以及治疗措施重要手段.本文就物理、化学和生物因素等致癌因素诱发胸腺瘤肿瘤模型作一回顾,并对其诱发机制以及影响因素作一概述.同时对诱发胸腺瘤模型的优点进行简单综述.Thymoma is the most common mediastinal tumor, its etiology and pathogenesis is unclear. It is an invasive important means to establish suitable animal model for studing its etiology, pathogenesis and treatment. In this paper, we review some thymoma tumor model induced by carcinogens such as physical, chemical and biological factors. At the same time their trigger mechanism and influenced factors were also reviewed Then we simply introduce the advantages of the induced thymoma model.

关 键 词：胸腺瘤 化学因素 EBV 电离辐射 动物模型 

分 类 号：R736.3[医药卫生—肿瘤] R-332[医药卫生—临床医学]