帕金森病抑郁症状对生活质量的影响及其相关因素分析  

Impact of depression on quality of life of Parkinson's disease and its associated factors

作　　者：马敬红[1] 邹海强[2] 孙菲[3] 安静[4] 陈彪[1] 

机构地区：[1]首都医科大学宣武医院神经内科,北京100053 [2]广州军区广州总医院神经内科,广州510010 [3]首都医科大学宣武医院流行病学和社会医学部,北京100053 [4]首都医科大学宣武医院老年病研究所,北京100053

出　　处：《首都医科大学学报》2011年第6期777-780,共4页Journal of Capital Medical University

基　　金：国家高技术研究发展计划(863计划)(2006AA02A408);国家重点基础研究发展计划(973项目)(2011CB504101)~~

摘　　要：目的探讨帕金森病(Parkinson's disease,PD)患者伴发抑郁症状的患病率,其对生活质量的影响及其相关因素。方法选取2008～2011年在首都医科大学宣武医院帕金森病专科就诊的原发性PD患者445例,详细记录其起病年龄、病程等临床资料。采用汉密尔顿抑郁量表(Hamilton Depression Rating Scale,HAMD)评价PD患者抑郁症状的严重程度,用统一帕金森病评分量表(Unified Parkinson's Disease Rating Scale,UPDRS)评价疾病的严重程度,用健康状况调查问卷(SF-36)评价患者的生活质量。结果 PD患者HAMD量表平均分值为7.42±6.44。其中无抑郁症状者占61.2%,轻度抑郁症状者占30.2%,中度抑郁症状者占6.5%,重度抑郁症状者占2.1%。帕金森病伴发抑郁症状的患者其SF-36生理机能评分、生理职能评分、情感职能评分、精力评分、精神健康评分、社会功能评分、躯体疼痛评分、一般健康状况评分、健康变化评分均低于无抑郁症状的PD患者(P<0.001)。Logistic回归分析表明UPDRS总分与抑郁症状呈正相关。结论 PD患者伴发的抑郁症状以轻度为主。抑郁症状对患者的生活质量有显著影响。病情越重出现抑郁症状的可能性越大。Objective To investigate the prevalence of depression,its impact on quality of life of Parkinson＇s disease（PD） and its associated factors. Methods The detailed clinical information of 445 patients with idiopathic PD were recorded.Hamilton Depression Rating Scale（HAMD） were used to assess the severity of depression in PD patients.Unified Parkinson＇s Disease Rating Scale（UPDRS） were used to evaluate the severity of PD.The Medical Outcomes Study 36-Item Short-Form Health Survey（SF-36） was used to assess the quality of life.The data was calculated with SPSS statistic software. Results The average score of HAMD was 7.42±6.44.Among the 445 patients,61.2% patients had no depressive symptoms,30.2% patients had minor depression,6.5% had moderate depression,and 2.1% had severe depression.Depression had significantly impacted the quality of life of PD in physical functioning,role-physical,role-emotional,vitality,mental health,social functioning,bodily pain,general health,and reported health transition（P0.001）.Logistic regression analysis showed that total UPDRS scores were positively correlated with depression. Conclusion The depression in patients with PD was mainly minor depression and it had significant negative effect on quality of life in PD patients.The more severe the disease is the more likely to develop depression.

关 键 词：帕金森病 抑郁 生活质量 

分 类 号：R742.5[医药卫生—神经病学与精神病学]