老年人认知状况及相关因素P300电位的临床研究  

Study on cognition and P300 potential of elder and correlative factor

作　　者：李六一[1] 穆俊林[2] 魏爱环[1] 魏延丽[1] 冯淑艳[1] 

机构地区：[1]河南省人民医院神经电生理室,河南郑州450003 [2]新乡医学院第二附属医院电生理研究室,河南新乡453002

出　　处：《中国医药科学》2011年第24期9-10,共2页China Medicine And Pharmacy

摘　　要：目的探讨P300电位测定在评估老年人认知功能状态中的价值。方法对62名较高学历老年人和60名较低学历老年人分别进行P300电位测定和认知能力筛查实验,并将测定结果加以比较。结果低学历组的P300电位成分中N2、P3波潜伏期延长及P3波幅降低,与高学历老年人组存在显著性差异(P<0.01);认知能力筛查实验测定9个因子分数及总分显示:低学历组均低于高学历组,两组存在显著性差异(P<0.01或P<0.05)。结论 P300电位可以作为评价老年人认知功能状况的一项客观指标。Objective To explore the effect of P300 potentials on the appraisal of cognition in elder. Methods P300 potentials test and cognitive ability screening instrument（CASI） were used for sixty-two well-educated elder and sixty normal-educated elder, the results were compared in the two groups. Results Latent periods of N2 and P3 in P300 potentials with normal-educated elder were longer and the amplitude of P3 was lower than those in the well-educated elder, there was significant difference between the two groups（P 〈 0.01）. CASI test shows that the nine factors scores and the total score in normal-educated elder were significantly lower than those in the well-educated elder（P 〈 0.01 or P〈 0.05）. Conclusion P300 potentials can be used in practice as a objective index to analyse cognition of elder.

关 键 词：老年人 认知状况 P300电位 

分 类 号：R741.044[医药卫生—神经病学与精神病学]