循环热灌注大剂量顺铂治疗胃肠道肿瘤腹水的临床研究  

Clinical study for ascites with gastrointestinal cancer with continued hyperthermic peritoneal perfusion high dose cisplatin in the treatment of ascites due to gastrointestinal cancer: a clinical study

作　　者：曹汝耀[1] 吕大鹏[2] 李万岱[1] 

机构地区：[1]河北省肃宁县人民医院,河北肃宁062350 [2]首都医科大学附属北京世纪坛医院,北京100038

出　　处：《中国医药科学》2011年第24期23-24,共2页China Medicine And Pharmacy

摘　　要：目的探讨循环热灌注大剂量顺铂治疗胃肠道肿瘤腹水的近期疗效,并对其并发症进行分析。方法 29例胃肠道肿瘤腹水患者通过腹腔内穿刺置双管建立循环双通路,先行单向灌洗放出腹腔积液;再行循环热灌注,并于灌注液中加入大剂量顺铂,观察其疗效及并发症。结果本组29例患者接受腹腔内循环热灌注大剂量顺铂2个疗程后评价疗效,均未出现肾脏毒性、腹膜炎、耳毒性、肠粘连和肠梗阻,其中完全缓解9例,部分缓解16例,稳定3例,无效1例,有效率为86.2%,16例(55.2%)患者出现胃肠道反应,9例(31.0%)患者出现白细胞下降。结论腹腔内循环热灌注大剂量顺铂化疗治疗胃肠道肿瘤腹水安全、微创、不良反应少而轻、近期疗效明显。Objective To explore the circulating hot infusion of high dose cisplatin in the treatment of gastrointestinal cancer ascites effect and analysis of its complications. Methods 29 cases of ascites in patients with gastrointestinal tumor through puncture with double tubes and established cycle double-pathway, one-way lavage released ascites. Further circulation perfusion, and joined the high-dose cisplatin in infusion liquid to observe its effects and complications. Results Of this group of 29 cases of patients being circulation perfusion after high-dose cisplatin the two course evaluation of efficacy, including complete remission 9, cases, part mitigation 16 cases, stability 3 cases, invalid 1 cases, has efficiency 86.2%, 16 cases （55.2%） patients appears gastrointestinal road reaction, 9 cases （31.0%） patients appears white cell fell, all patients in the is not appears kidney toxicity, and ear toxicity, and peritoneal inflammatory, and intestinal adhesion, and intestinal obstruction. Conclusion Loop infusion high dose cisplatin chemotherapy in the treatment of gastrointestinal tumor ascites safe, minimally invasive, less side effects and recent effect of light and obvious.

关 键 词：循环热灌注 大剂量顺铂 胃肠道肿瘤 腹水 

分 类 号：R730.53[医药卫生—肿瘤] R735[医药卫生—临床医学]