奥卡西平和碳酸锂治疗双相障碍躁狂发作患者的对照研究  

A comparative study of oxcarbazepine and lithium in the treatment of bipolar disorder with manic episode

作　　者：老帼慧[1] 曾奕彬[1] 王西林[1] 郝小玉[1] 老洪尧[1] 

机构地区：[1]广州市脑科医院,510370

出　　处：《临床精神医学杂志》2011年第6期419-421,共3页Journal of Clinical Psychiatry

摘　　要：目的:比较奥卡西平和碳酸锂治疗双相障碍躁狂发作的疗效和安全性。方法:70例双相障碍躁狂发作患者随机分为奥卡西平组和碳酸锂组各35例,分别给予奥卡西平和碳酸锂治疗8周。以Bech-Rafaelsen躁狂量表(BRMS)、临床疗效总评量表-病情严重程度(CGI-SI)以及治疗中出现的症状量表(TESS)评定疗效及不良反应。结果:两组治疗后BRMS、CGI-SI评分均较治疗前显著下降(P<0.05或P<0.01);两组间比较差异无统计学意义(P>0.05);两组不良反应均为轻度。结论:奥卡西平治疗双相障碍躁狂发作的疗效与碳酸锂相当,不良反应轻。Objective：To explore the efficacy and safety of oxcarbazepine and lithium in treatment of bipolar disorder with mania episode. Method：70 patients with bipolar disorder with mania episode randomized into single used oxcarbazepine group（35 cases） and lithium group（35 cases） for 8 weeks.Bech-Rafaelsen manic scale（BRMS） ,clinical global impressions severity scale（CGI-SI） and treatment emergent symptoms scale（TESS） were used to evaluate efficacy and side effects. Results：After treatment,BRMS and CGI-S score decreased significantly compared with before treatment（P0.05 or P0.01） ,there were no significant difference between two groups in score of BRMS and CGI-S（P0.05） .Two groups adverse events were mild. Conclusion：Oxcarbazepine and lithium are both effective and safe,in the treatment of bipolar disorder with manic episode.

关 键 词：双相障碍躁狂发作 奥卡西平 碳酸锂 

分 类 号：R749.4[医药卫生—神经病学与精神病学]