结直肠呈高度异型增生或早期癌变腺瘤临床病理分析  

Clinical Analysis of Pathological Factors for High-grade Colorectal Dysplasia or Adenoma-cauded Primary Carcinoma

作　　者：胡其泰[1] 胡凤英[1] 杨莉[2] 田旭阳[2] 陈言东[2] 孟宪梅[2] 

机构地区：[1]包头医学院,内蒙古包头014060 [2]包头医学院第二附属医院

出　　处：《包头医学院学报》2011年第6期15-18,共4页Journal of Baotou Medical College

摘　　要：目的:分析结直肠腺瘤病人特征和腺瘤特征,探讨结直肠呈高度异型增生或早期癌变腺瘤的危险因素。方法:比较经整体结肠镜检查检出的259例腺瘤患者中结直肠呈高度异型增生或早期癌变腺瘤与结直肠呈低度异型增生腺瘤在病人特征、腺瘤特征之间的关系。结果:259例腺瘤患者年龄58.9±12.3岁,共切除376枚腺瘤或早期癌变腺瘤;75例病人(29.0%)发现99枚(26.3%)呈高度异型增生或早期癌变腺瘤。结论:多发腺瘤、大于1.0 cm的腺瘤、管状绒毛状或绒毛状腺瘤是高度异型增生和早期癌变腺瘤的危险因素。Objective： To investigate the risk factors for high-grade dysplasia and adenoma-induced primary carcinoma through analyzing characteristics of both the colorectal adenoma patients and adenoma itself.Methods： Out of 259 cases of adenoma diagnosed through complete colonoscopy at our institute,both patient characteristics and adenoma characteristics were compared between the cases with either high-grade dysplasia or adenoma-induced primary carcinoma and those with low-grade dysplasia so as to find out potential differences.Results： The average age for the 259 patients was 58.9±12.3 and the total number of adenomas or adenoma-induced primary carcinoma resected from these patients was 376.Out of the 376,99 adenomas（26.3 %） from 75 patients（29.0 %） were found out to be high-grade dysplasia or adenoma-induced primary carcinoma.And the risk factors for high-grade dysplasia or adenoma-induced primary carcinoma include the occurrence of multiple adenomas,adenomas greater than 1.0 cm in size,tubulovillous adenoma or villous adenoma.Conclusion： It is of great importance to take the following measures： to reasonably resect adenomatous polyps with the development of either multiple adenomas,or adenoma greater than 1.0 cm in size,or tubulovillous adenoma or villous adenoma,to accurately make pathological diagnosis as well as necessary follow-up observation,which ought to be highly appreciated by both endoscopists and pathologists as well.

关 键 词：结直肠 腺瘤 息肉 异型增生 早期癌变 危险因素 

分 类 号：R735.3[医药卫生—肿瘤]