颅内外动脉狭窄支架植入手术前后血清胱抑素C水平变化及对动脉再狭窄的影响  

On the Change of Serum Cystatin C Brought by the Stent Implantation for Intracranial or Extracranial Arterial Stenosis and the Influence to Restenosis

作　　者：彭日红[1,2] 阳洪[1,2] 贺雄军[3] 翁保慧[1,2] 

机构地区：[1]广西医科大学第四附属医院 [2]柳州市工人医院神经内科,广西壮族自治区柳州市545005 [3]南方医科大学附属珠江医院神经内科

出　　处：《中国全科医学》2011年第36期4203-4204,4207,共3页Chinese General Practice

摘　　要：目的探讨颅内外动脉狭窄支架植入手术前后血清胱抑素C(Cys-C)的水平变化及其对动脉再狭窄的影响。方法选取2008—2010年47例颅内外动脉狭窄患者进行血管内支架植入术治疗,术后6～12个月复查数字减影血管造影(DSA),分别于术前、术后3 d和复查DSA时检测患者血清Cys-C水平,并对比分析动脉再狭窄组与未狭窄组的血清Cys-C水平。结果术后6～12个月复查DSA显示,21例(44.7%)患者出现了再狭窄,其中13例再狭窄率<50%,8例再狭窄率≥50%,26例患者未发现血管明显再狭窄。再狭窄组术前及术后3 d的血清Cys-C水平分别与未狭窄组比较,差异均无统计学意义(P>0.05);再狭窄组和未狭窄组术后3 d的血清Cys-C水平与术前比较,差异均有统计学意义(P<0.05);再狭窄组术后6～12个月的血清Cys-C水平分别与术前及未狭窄组比较,差异均有统计学意义(P<0.05)。结论支架术后血清Cys-C水平的增高可能与再狭窄有关,并可能成为评价缺血性脑血管病复发的一个指标。Objective This paper describes the change of serum cystatin C （ Cys - C） brought by the stent implantation for intracranial or extracranial arterial stenosis and the influence to restenosis. Methods The stent implantation （2008-- 2010） for 47 patients with intracranial or extracranial arterial stenosis were chosen. We recheck the Digital Subtraction Angiography （DSA） 6 - 12 months after the stent implantation, detect the 3 d Cys -C before and after the operation and the Cys -C when the DSA was rechecked. Then we compare and analyze the Cys - C of the restenosis group and that of the normal group. Results The rechecking of the DSA 6 - 12 months after the operation showed that 21 patients （44. 7% ） had restenosis, among which in 13 cases, the rate of restenosis was less than 50%, in 8 cases the rate was no less than 50%, 26 patients had no obvious restenosis. Compared with the normal group, before and after the operation, the 3 d Cys - C of the restenosis group had no statistical significance （ P 〉 0. 05） . The 3 d Cys - C of beth the restenosis group and the normal group were higher than that before the operation （P 〈 0.05） ; the Cys - C of the restenosis group was higher than that of the normal group, when the DSA was rechecked 6 - 12 months after the operation （P 〈0. 05） . Conclusion The increase of Cys - C after the stent implantation may be related to restenosis, which might become an index to analyze the relapse of ischemic cerebrovascular disease.

关 键 词：脑动脉疾病 支架 胱抑素C 再狭窄 

分 类 号：R743[医药卫生—神经病学与精神病学]