多因子诱导的杀伤细胞联合白介素-2胸腔内注射治疗癌性胸腔积液的临床疗效观察  

Clinical Efficacy of CIK Cells and Combined Intracavitary Injection of IL-2 in the Treatment of Malignant Pleural Effusion

作　　者：王娟[1] 陶贞霞[1] 刘荣英[1] 曹艳丽[1] 国虹[1] 蔡秀萍[1] 许卫星[1] 王建华[1] 吴秀然[1] 李海玲[1] 

机构地区：[1]河北省沧州市中心医院血液一科,061001

出　　处：《中国全科医学》2011年第35期4108-4110,共3页Chinese General Practice

基　　金：2006年河北省医学适用跟踪项目

摘　　要：目的探讨多因子诱导的杀伤细胞(CIK)联合白介素-2胸腔内注射治疗癌性胸腔积液的疗效。方法采集15例癌性胸腔积液患者外周血单个核细胞,加入CD3单抗、γ-干扰素、重组人白介素-2诱导成CIK细胞,部分CIK细胞静脉输注,部分CIK细胞联合白介素-2胸腔内注射。结果治疗后患者外周血T细胞亚群的NK细胞(CD1+6CD5+6双阳性细胞)较治疗前明显上升,差异有统计学意义(P<0.05);患者的临床症状、影像学均提示病变较前好转。结论 CIK细胞联合白介素-2胸腔内注射治疗癌性胸腔积液有确切疗效,提高了患者的生活质量。Objective To assess the therapeutic effects of CIK cells and combined intracavitary injection of IL -2 in treating malignant pleural effusion. Methods Peripheral blood mononuclear cells were isolated from 15 patients with malignant pleural effusion. CIK cells were induced by CD3 monoclonal antibody, γ-INF and IL -2 and injected partially via the vein and partially into the thoracic cavity together with IL-2. Results After treatment, peripheral NK cells （CD16^＋CD56^＋double positive ceils） were increased significantly （P 〈 0. 05）. Clinical symptoms and iconography of the patients were all improved. Conclu- sion It is definitely effective to treat malignant pleural effusion with CIK ceils and combined intracavitary injection of IL - 2, which prolongs the survival and improves the life quality of the patients.

关 键 词：胸腔积液 癌性 杀伤细胞 白细胞介素2 

分 类 号：R734.2[医药卫生—肿瘤]