宫颈癌与性传播因子的探讨  

DISCUSSION OF THE RELATIONSHIP BETWEEN CANCER OF THE UTERINE CERVIX AND SEXUAL PESTIFEROUS FACTORS

作　　者：郑曙民[1] 孙立新[1] 武燕[1] 岳丽萍[1] 黄慧[1] 石利香[1] 付静波[1] 

机构地区：[1]山西省肿瘤医院,山西太原030013

出　　处：《肿瘤研究与临床》2000年第1期21-22,共2页Cancer Research and Clinic

摘　　要：目的:探讨宫颈癌的发生与性传播因子人乳头瘤病毒(HPV)16、18、35型、单纯疱疹病毒(HSV)2型、沙眼衣原体(CT)的关系。方法:应用聚合酶链反应(PCR)对195例宫颈癌的癌组织、51例非宫颈癌、32例健康妇女的正常宫颈组织进行检查。结果:宫颈癌HPV16、18、35型、HSV2型和CT的阳性率分别为:31.79%、30.77%和5.64%,非宫颈癌的阳性率分别为:3.92%、3.92%和1.96%,正常妇女的阳性率分别为:3.13%、6.24%和3.13%。宫颈癌组HPV16、18、35型及HSV2型明显高于非宫颈癌组和正常妇女组(P<0.001),而CT感染则无明显差异(P>0.05)。结论:宫颈癌的发生与HPV16、18、35型及HSV2型感染密切相关。Objective:To study the relationship between occurrence of carcinoma of the uterine cervix and sexual pestiferous factors including human papilloma virus (HPV) type 16,18,35,simple herpes virus (HSV) type Ⅱ and chlamydia trachoma (CT).Methods:Using polymerase chain reaction (PCR),we detected cancerous tissues of carcinoma of the uterine cervix in 195 cases,cervical tissues of non carcinoma of the uterine cervix in 51 cases and normal cervical tissues of healthy women in 32 cases.Results:Infectious masculine rates of HPV16,18,35,HSVⅡ and CT in the carcinoma of the uterine cervix group were 31.79%,30.77% and 5.64% respectively.In the non carcinoma group of the uterine cervix they were 3.92%,3.92% and 1.96%.In the normal women group, they were 3.13%,6.24% and 3.13% respectively.Infectious masculine rates of HPV 16,18,35 and HSVⅡ. In the carcinoma group of the uterine cervix group they were higher than those in the other two groups (P<0.001).There were no statistical differences between masculine rate of CT in the carcinoma of the uterine cervix group and those in the other two groups. But masculine rate in the first group was higher than those in the other two groups obviously .Conclusion:HPV16,18,35 and HSVⅡ were related to the occurrence of carcinoma of the uterine cervix closely.Function of CT should be paid more attention to the occurrence of carcinoma of the uterine cervix.

关 键 词：宫颈癌 乳头瘤病毒 单纯疱疹病毒 沙眼衣原体 

分 类 号：R737.33[医药卫生—肿瘤]