Survivin、Ki-67核抗原在宫颈癌及宫颈上皮内瘤变中的表达意义  

Expression and significance of Survivin,Ki-67 in cervical carcinoma and cervical intraepithelial neoplasia

作　　者：田琦[1] 吕胜军[2] 

机构地区：[1]吉林省肿瘤医院放疗科,吉林长春130012 [2]吉林省肝胆病医院电诊科,吉林长春130062

出　　处：《中国实验诊断学》2011年第12期2067-2069,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨生存素(Survivin)、Ki-67核抗原在宫颈癌和宫颈上皮内瘤变(CIN)中的表达及生物学意义。方法采用免疫组化S-P法,检测26例宫颈癌,78例宫颈上皮内瘤变(CINⅠ28例,CINⅡ23例,CINⅢ27例)及12例正常宫颈组织中Survivin、Ki-67的表达水平。结果 Survivin、Ki-67核抗原在正常宫颈组织、CIN及宫颈癌中的表达依次递增,Ki-67核抗原的表达随Survivin表达增加而上升,统计学上差异有显著意义(P<0.05)。结论 Survivin、Ki-67核抗原在宫颈癌中的异常表达,可能与宫颈癌发生、发展过程中凋亡抑制和增殖能力增强有关。Objective To investigate the expression and the biological significance of Survivin,Ki-67 in the cervical carcinoma and the cervical intraepithelial neoplasia（CIN）.Methods Immunohistochemical technique was used to detect the expression of regulators Survivin and Ki-67 in 26 case of cervical carcinoma,78 case of cervical intraepithelial neoplasia（CINⅠ28例,CINⅡ23例,CINⅢ27例）and 12 case of normal cervical tissures.Results Expressions of Survivin and Ki-67 nuclear antigen in normal cervical tissures,CIN and cervical carcinoma were gradually increased（P0.05）.The expression of Ki-67 was increased with the increment of Survivin expression（P0.05）.Conclusion The abnormal expression of Survivin and Ki-67 nuclear antigen with cervical carcinoma,may be relate with the cell apoptosis and poliferation.

关 键 词：宫颈癌 宫颈上皮内瘤变 SURVIVIN KI-67 

分 类 号：R737.33[医药卫生—肿瘤]