P53、P21^(ras)基因在子宫内膜非典型增生和子宫内膜癌中的表达分析  

Expression of P53 and P21 Gene in Atypical Endometrial Hyperplasia and Endometrial Cancer

作　　者：仁欠 郭新建[2] 于志敏[2] 侯俊磊[2] 

机构地区：[1]青海省贵德县人民医院,811700 [2]青海大学附属医院病理科,810000

出　　处：《青海医药杂志》2011年第10期9-10,共2页Qinghai Medical Journal

摘　　要：目的:探讨P53和P21ras基因在正常子宫内膜、子宫内膜非典型增生和子宫内膜癌中表达情况,及其表达在病理诊断中的意义。方法:应用免疫组织化学方法检测15例正常子宫内膜、12例子宫内膜非典型增生和35例子宫内膜癌中P53和P21ras的表达情况。结果:15例正常子宫内膜中P53和P21ras基因表达阴性;12例子宫内膜非典型增生中2例P53阳性(16.6%)、1例P21ras阳性(8.3%);在子宫内膜癌中P53阳性20例(57.1%)、17例P21ras阳性(48.0%)。结论:P53和P21ras基因在子宫内膜增生性疾病中均有表达,在子宫内膜癌中高表达(,P<0.05),对子宫内膜癌的病理诊断提供有力依据。Objective：To deal with expression and its significance of P53 and P21 r, gene in Atypical endometri- al hyperplasia and endometrial cancer. Methods：The expression of P53 and P21st of endometrium were measured by immunohistochemistry assay in 15 normal endometrial women, 12 atypical hyperplasia women and 35 women with endometrial cancers. Results：The expression of P53 and P21st gene showed negative in normal group, I753 and P21st gene expressed positively was 2 （ 16.6% ） and 1 cases （ 8.3% ） in atypical endometrial hyperplasia group respectively, and 20 （57.1%） and 17 cases （48.6%） in endometrial cancers respectively. Conclusions： There is an expression of P53 and P21st gene in endometrial hyperplasia diseases, especially higher in patients with endometrial cancer.

关 键 词：子宫内膜癌 非典型性增生 癌基因 P53 和 P21RAS 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]