体外环境下纤溶酶及不同载药量对纤维蛋白胶缓释作用影响  

Investigation on the Influencing Factors between Plasminogen and Different Drug Loading for Released from Fibrin Glue in Vitro

作　　者：申维喜[1] 杨宇[1] 姜秋颖[1] 黄丽军[2] 张倩 黄大勇[1] 王文秀[1] 齐丽萍[1] 邵蔓丽[1] 

机构地区：[1]哈尔滨医科大学附属第二医院肿瘤内科,黑龙江哈尔滨150086 [2]哈尔滨医科大学附属二院药学部,黑龙江哈尔滨150086 [3]北京庇利积臣医院门诊部,北京100027

出　　处：《黑龙江医药》2011年第6期894-897,共4页Heilongjiang Medicine journal

基　　金：黑龙江省教育厅科研基金资助项目(项目编号1511218)

摘　　要：目的:考察纤溶酶及不同载药量对顺铂-纤维蛋白胶复合物在体外缓释作用的影响。方法:采用衍生-紫外分光光度法对顺铂-纤维蛋白胶复合物体外释放样本进行测定。观察纤溶酶对不同载药量纤维蛋白胶(fibrin glue,简称FG)的释放过程是否存在影响。结果:溶介为纤溶酶时早期(24h)药物释放相对较快,1h和24h时间点溶液中药物浓度存在差异(p<0.05)。结论:体外环境下纤溶酶对顺铂-纤维蛋白胶复合物(CDDP/FG)缓释过程早期存在影响。不同载药量对其缓释作用无影响。Objective：To investigate on the influencing factors between plasminogen and different drug loading for CDDP re- leased from fibrin glue in vitro respectively. Methods：The derivatives - UV spectrophotometry was used to determine the samples of cisplatin - fibrin complex - glue and to observe whether it effected the drug delivery between the plasminogen and different drug loading. Results：For the plasmin -mediated dissolution at an early stage （24h）drug release is relatively fast, l h and 24h time points drug concentrations in solution are different（P 〈0. 05）. Condusion：Plasmin in vitro environment,eisplatin - fibrin glue eomplexes（CDDP / FG） during the early stage of slow- release effect. different drug loading had no effect on their releas.

关 键 词：顺铂 纤维蛋白胶 缓释作用 

分 类 号：R735.7[医药卫生—肿瘤]