顺-6-氟-3-氯代亚甲基-硫色满-4-酮的体内抗肿瘤活性研究  

Antitumor activity of 3-chloromethylene-6-fluoro-thiochroman-4-one in vivo

作　　者：杨春柳[1] 李佳[1] 杨更亮[1] 

机构地区：[1]河北大学药学院河北省药物质量分析控制重点实验室,河北保定071002

出　　处：《医学研究与教育》2011年第6期13-18,共6页Medical Research and Education

基　　金：国家自然科学基金(20375010;20675084);河北省重点实验室专项(08669209D);河北省教育厅重点项目(ZD2010234)

摘　　要：目的探讨顺-6-氟-3-氯代亚甲基-硫色满-4-酮(CMFT)的急性毒性及体内抗肿瘤活性。方法考察CMFT的急性毒性,建立移植性肿瘤模型,通过灌胃和腹腔注射给药考察CMFT的体内抗肿瘤活性。结果 CMFT毒性较低,可显著抑制H22肝癌细胞小鼠皮下移植瘤的生长,并明显延长S180腹水瘤小鼠的存活时间。结论该化合物具有较高的体内抗肿瘤活性且毒性较低,值得对其进行深入研究。Objective To explore the antitumor effect and acute toxicity of 3-chloromethylene-6-fluoro- thiochroman-4-one（CMFT） in vivo. Methods In this experiment tumor cells were inoculated subcutaneous in mice. The infected mice were treated by CMFT with the method of intragastric administration or peritoneal injection. Results CMFT was low toxicity and solid tumor caused by H22 can be inhibited obviously by CMFT and the live time of the mice implanted ascitic tumor S180 were prolonged. Conclusion These show that the compound which possess significant antitumor activity in vivo and low toxicity is deserved to be studied further.

关 键 词：顺-6-氟-3-氯代亚甲基-硫色满-4-酮 抗肿瘤活性 H22移植性肿瘤模型 S180腹水瘤模型 

分 类 号：R730[医药卫生—肿瘤]