MMP7蛋白及mRNA在卵巢上皮性肿瘤中的表达及意义  

The expression and significance of MMP7 protein and mRNA in epithelial ovarian carcinoma

作　　者：宋敬[1] 李越[2] 蔡雁[1] 张玮[1] 苏丽杰[1] 

机构地区：[1]哈尔滨医科大学附属第四医院妇产科,哈尔滨150001 [2]黑龙江省医院

出　　处：《实用肿瘤学杂志》2011年第6期512-515,共4页Practical Oncology Journal

基　　金：黑龙江省卫生厅资助项目合同编号（2011-159）

摘　　要：目的 探讨MMP7在上皮性卵巢癌组织中的表达及临床意义.方法 采用免疫组化方法及原位杂交方法检测10例正常卵巢组织、10例良性上皮性卵巢肿瘤组织和54例上皮性卵巢癌组织中MMP7蛋白的表达.结果 正常卵巢组织及良性卵巢肿瘤组织中,MMP7蛋白不表达;上皮性卵巢癌组织中,MMP7阳性表达率为88.89%.MMP7的表达与上皮性卵巢癌的临床分期和病理分级有关,与淋巴结转移无关.MMP7的mRNA与蛋白表达呈正相关（P＜0.0001）.结论 上皮性卵巢癌组织中,MMP7蛋白高度表达.MMP7蛋白在上皮性卵巢癌的发生过程中发挥着重要的作用,MMP7蛋白及mRNA表达水平可以作为判断卵巢癌预后的指标.Objective To determine the clinical significance of MMP7 protein expression in patients with epithelial ovarian cancer （EOC）. Methods MMP7 expression was evaluated using immunohistochemical and in situ hybridization in 10 normal ovarian tissues, 10 benign ovariantumors and 54 EOCs. Results MMP7 was not expressed in normal ovarian tissues and benign ovarian tumors. The rate of positive expression of MMP7 in EOC cells is 88.89%, and the expression of MMP7 in EOC was correlated with clinical stage and pathological grades, but not with lymph node metastasis. The expression of MMP7 and mRNA also had positive correlation in EOC（P〈0.0001）. Conclusion MMP7 expression is up regulated in EOC. It plays an important role in the tumor growth of EOC. MMP7 protein and mRNA may be used as a prognostic factor in EOC.

关 键 词：基质金属蛋白酶7 免疫组化 原位杂交 卵巢癌 

分 类 号：R737.31[医药卫生—肿瘤]