经直肠超声引导前列腺穿刺活检方案的合理选择  

Reasonable scheme option of prostate biopsy guided by transrectal ultrasound

作　　者：高晶[1] 张艳华[1] 李龙[1] 李红梅 汤丽丽[1] 李洁冰[1] 

机构地区：[1]哈尔滨医科大学附属第三医院超声科,哈尔滨150081 [2]威海金海湾医院超声科

出　　处：《实用肿瘤学杂志》2011年第6期516-519,共4页Practical Oncology Journal

基　　金：黑龙江省自然科学基金（D2007-32）;哈尔滨市科技创新人才研究专项基金（2007RFQXS087）

摘　　要：目的 分析经直肠超声（TRUS）和前列腺特异性抗原（PSA）及其相关参数在前列腺穿刺活检中的作用,探讨个体化前列腺穿刺方案的可行性.方法 回顾性分析195例患者的首次穿刺活检资料,所有患者均采用系统8点穿刺方案,并对可疑病灶增加1～2点.依据穿刺病理结果,分析前列腺癌（Pca）检出率与TRUS、PSA及其相关参数的关系.结果 195例患者中检出Pca 98例（50.3%）,其中PSA 4～10ng/mL组45例,检出Pca 16例（35.6%）,其中TRUS（＋）且PSATZ≥0.35ng/mL2 210例均证实为Pca;PSA＞10 ng/mL组150例,检出Pca 82例（54.7%）.PSA 4～10 ng/mL与PSA＞10 ng/mL两组患者Pca检出率差异有统计学意义（P＜0.05）,且两组中TRUS（＋）与TRUS（-）患者相较Pca检出率差异均有统计学意义（P＜0.01）.结论 依据TRUS、PSA及其相关参数制定个体化前列腺穿刺方案是可行的.Objective To evaluate the role of transrectal uhrasonography（ TRUS）, serum PSA and relavant parameters in prostate biopsy,investigate the feasibility of individualization of prostate biopsy strategies based on TRUS,serum PSA and relavant parameters. Methods Clinical data of 195 patients who had been carried out the first TRUS guided prostate biopsy were reviewed. The 8 - core strategies were chosen in the patients. The suspicious lesions were increased I -2 points biopsy. The association between prostate cancer（PCa） detection rate and patientsTRUS,PSA levels and relavant parameters was analyzed according to the biopsy results. Results 98 cases（50.3% ）had PCa in 195 patients. Of 45 patients with PSA between 4 - 10 ng/mL,16 patients（35.6% ） had PCa. Of 10 patients with TRUS（ ＋ ）and PSATZ ≥0.35 ng/mL2, all had PCa on pathological positive. Of ! 50 patients with PSA 〉 10 ng/mL, 82 patients （54.7%）had PCa. There were statistical significant differences be- tween the patients with PSA between 4 - 10 ng/mL and PSA 〉 10ng/ml two groups in the PCa detection rates, it was also found that there was statistical significance between TRUS（ ＋ ）and TRUS（ - ）. Conclusion Individu- alization of the prostate hiopsy strategies according to TRUS,serum PSA and relavant parameters is feasible.

关 键 词：超声检查 前列腺特异抗原 前列腺肿瘤 活组织检查 针吸 

分 类 号：R730.44[医药卫生—肿瘤]