抑癌基因PML在宫颈病变组织中的表达  

Expression of Tumor Suppressor Genes PML in Cervical Lesions

作　　者：林云恩[1] 李清秀[1] 王莉[1] 谭佩婵[1] 刘桂红[1] 何志晖[1] 

机构地区：[1]广东省广州市广州医学院第一附属医院,广州510120

出　　处：《中国卫生产业》2011年第12期20-22,共3页China Health Industry

基　　金：广东省医学科学技术研究基金资助项目(A2008260)

摘　　要：目的探讨抑癌基因早幼粒细胞性白血病基因(promyelocytie leukemia,PML)在宫颈病变组织中表达量的变化。方法选取以下宫颈病变新鲜组织标本,包括宫颈上皮内瘤样病变I级(Cervical Intraepithelial Neoplasia,CINI)28例、CINII20例、CINIII26例、宫颈原位癌18例、宫颈浸润鳞癌I期21例、II期21例、III期6例、IV期2例、复发性宫颈癌2例(包括宫颈癌腹腔转移组织1例)以及因其他疾病切除子宫病理证实为慢性宫颈炎者30例。用免疫组化的方法检测PML在各种宫颈病变组织中的表达量。结果 PML的表达量随着宫颈病变严重程度的增加而增加(c2=113.02,P<0.00、r=0.26,P<0.00)。结论 PML的表达与宫颈病变的严重程度呈正相关。Objective To study the expression of tumor suppressor gene PML in cervical lesions. Methods Selected the following fresh tissue samples of cervical lesions, including 28 cases of CIN I, 20 cases of CIN II, 25 cases of CIN HI, 18 cases of carcinoma in situ of cervix, 21 cases of squamons cell carcinoma stage I, 21 cases of stage II, 6 cases of stage III, 2 cases of stage IV, 2 cases of recurrent squamons cell carcinoma and 30 cases of chronic cervicitis. Immunohistochemistry method was used to detect the expression of PML protein in the samples. Results PML expression increased with progression from chronic cervicitis, CIN to squamons cell carcinoma （X^2=113.02, P（0.00, r=0.26, P〈0.00）. Conclusion PML expression and the severity of cervical lesions are positive related.

关 键 词：抑癌基因 早幼粒细胞性白血病基因 宫颈病变 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]