蛙皮活性抗菌肽最新研究进展  

Progress in Research of Active Antimicrobial Peptides from the Skins of Frog

作　　者：周庆峰[1] 赵文锋[2] 张向飞[3] 

机构地区：[1]商丘师范学院生命科学系,河南商丘476000 [2]中国药科大学生命科学学院,南京210009 [3]商丘师范学院化学系,河南商丘476000

出　　处：《中国农学通报》2011年第33期217-220,共4页Chinese Agricultural Science Bulletin

基　　金：国家自然科学基金资助项目"蛙皮抗菌肽Brevinin-2GUb促胰岛素释放作用及其分子机制研究"(30901877);河南省科技厅科技攻关资助项目"Tβ4-INS融合表达蛋白用于治疗糖尿病皮肤溃疡的研究"(092102310209);商丘师范学院骨干教师资助项目

摘　　要：蛙皮抗菌肽是生物界中广泛存在的一类生物活性肽,是蛙类生物机体先天性免疫系统中的重要成分。目前,从青蛙皮肤中获得了越来越多结构新颖、作用独特的活性抗菌肽,有望成为感染类以及糖尿病等疾病新的药物资源。此文通过对国内外相关文献进行检索,综合了国内外近年来的研究,对近年来蛙皮抗菌肽的活性研究概况进行综述。Antimicrobial peptide from the skins of frog is a kind of bioactive peptide existed extensively in nature, and is one key component of the host-resistance apparatus so-called innate immunity. At present, a series of antimicrobial peptide with novel structures and unique function were isolated from frog resources, which were potential resources for anti-infective and diabetes therapeutic drug. By literature retrieval and induction, the progress in research of antimicrobial peptide from the skins of frog was reviewed in this paper.

关 键 词：蛙皮 抗菌肽 促胰岛素释放 活性 

分 类 号：R963[医药卫生—微生物与生化药学]