双重膜血浆置换疗法治疗恶性浆细胞病的疗效观察  

The curative effect observation ofdouble membrane plasmapheresis therapy in the treatment of malignant plasma cell disease

作　　者：于春杰[1] 李子龙[1] 

机构地区：[1]中国医科大学第一临床医院肾内科,110001

出　　处：《中国现代药物应用》2011年第24期20-21,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨恶性浆细胞病的治疗进展。方法回顾分析我院血液科2001年9月至2008年4月期间诊断按《血液病诊断及疗效标准》确诊为恶性浆细胞病。住院患者12例的临床资料。未化疗或化疗前、后应用双重膜血浆置换疗法进行治疗,观察疗效。结果血浆IgG、IgA、IgM及r球蛋白水平显著下降,血色素、肾功能无明显变化。双重膜血浆置换疗法但血小板计数显著减少。结论双重膜血浆置换疗法能够迅速有效清除恶性浆细胞病中异常分泌的单克隆(同源的)免疫球蛋白。延缓疾病的发展,为疾病的基础治疗创造条件。Objective To explore the treatment progress of malignant plasma cell dyscrasia. Methods Retrospective analysis of our hospital in 2001 September to 2008 April blood during diagnosis according to＂ standard of diagnosis and treatment of Hematology＂ diagnosed as malignant plasma cell dyscrasia. The clinical data of 12 cases of hospitalized patients. Chemotherapy or chemotherapy before, after the application of double membrane plasmapheresis therapy for treatment, curative effect. The results show that the plasma levels of Ig- GIgAIgM and R globulin levels decreased significantly hemoglobin, renal function did not change significantly. Double membrane plasmapheresis therapy but the platelet count decrease. Conclusion Double membrane plas- mapheresis therapy can effectively and rapidly remove malignant plasma cell disorders in abnormal secretion of monoclonal immunoglobulins （ homologous ）. Slow the progress of the disease, is a disease based treatment for conditions.

关 键 词：恶性浆细胞病 双重膜血浆置换疗法 疗效观察 

分 类 号：R733[医药卫生—肿瘤]