地黄苏合香合剂对早期肝性脑病大鼠脑内外周型苯二氮受体的影响  

Effects of Rehmannia and Storesin on Peripheral-type Benzodiazepine Receptors in Early Hepatic Encephalopathy Rats

作　　者：刘赫[1] 刘雁勇[1] 杨楠[1] 纪超[1] 左萍萍[1] 龚韬 廖磊 侯晓明 蔡哲[3] 

机构地区：[1]中国医学科学院基础医学研究所,北京协和医学院基础学院药理室,北京市100005 [2]北京市中药研究所中药化学室,北京市100035 [3]卫生部中日友好医院临床医学研究所免疫学研究室,北京市100029

出　　处：《中国康复理论与实践》2011年第12期1121-1123,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金项目(30873390);北京中医药科技项目(JJT2007-001);科技部重大新药创制科技专项项目(2009ZX09303)

摘　　要：目的观察中药地黄、苏合香(地苏合剂)对早期肝性脑病大鼠脑皮层线粒体外周型苯二氮受体(PBRs)活性的影响。方法采用CCl4致化学性肝损伤大鼠模型,阳性药组给予乳果糖6 g/kg,治疗组分别给予不同剂量的地苏合剂,同位素法检测PBRs。结果模型组PBRs结合活性较对照组明显升高(P<0.01),中、高剂量组PBRs结合活性较模型组降低(P<0.05);模型组脑皮层线粒体PBRs的最大结合容量(Bmax)值较对照组明显升高(P<0.01),高剂量组较模型组明显降低(P<0.01)。结论地苏合剂可能通过降低早期肝性脑病大鼠脑皮层线粒体PBRs结合活性,减少神经损伤,从而延缓肝性脑病的发生、发展。Objective To assess the effects of Rehmannia and Storesin（RS） on peripheral-type benzodiazepine receptors（PBRs） in early hepatic encephalopathy（HE） rats.Methods CCl4 was used to induce the HE model.The benzodiazepine binding sites of PBRs in rats cortex were studied using the specific ligands PK11195.Lactulose was used in the positive medicine group,and the treatment groups received different dosages of RS.Results The specific binding and the Bmax value of PK11195 both significantly increased in the model group than in the control group（P0.01）.The specific binding decreased in the medium dosage group and the high dosage group than in the model group（P0.05）,and the Bmax value of PK11195RS-H decreased in the high dosage group than in the model group（P0.01）.Conclusion Rehmannia and Storesin is effective on early HE rats by decreasing the specific binding of PBRs,which could reduce the neural injury.

关 键 词：地黄 苏合香 肝性脑病 外周型苯二氮受体 大鼠 

分 类 号：R747.9[医药卫生—神经病学与精神病学]