苯二氮类药物治疗慢性酒精中毒伴精神障碍32例临床分析  

Clinical Analysis on Benzodiazepine Drugs in the Treatment of Chronic Alcoholism with Mental Disorder

作　　者：刘月芬[1] 郭金刚[1] 李全兵[1] 于利燕[1] 

机构地区：[1]中国河北联合大学附属开滦精神卫生中心,唐山063000

出　　处：《中国健康心理学杂志》2011年第12期1428-1429,共2页China Journal of Health Psychology

摘　　要：目的探讨慢性酒精中毒伴精神障碍患者应用苯二氮类药物治疗的效果。方法根据患者及其家属自愿情况,将患者随机分为对照组与观察组;对照组选用氯丙嗪控制精神症状,观察组用苯二氮类药物(选用地西泮)对症治疗;两组都给予维生素及心理治疗。结果对照组与观察组临床症状、认知功能、生活质量、住院天数比较,治疗前PANSS、WCST及WHO.QOL-100分值无统计学差异(t=0.75,P>0.05);治疗后PANSS、WCST及WHO.QOL-100分值比较有统计学差异(t=6.48,P<0.05)。结论观察组患者精神症状、认知功能、生活质量恢复明显快于对照组,苯二氮类药物对慢性酒精中毒伴精神障碍的治疗效果显著。Objective To analyze the efficacy of benzodiazepine drugs in the treatment of chronic alcoholism patients. Methods According to the patients and their families voluntarily, the patients were randomly divided into control group and observation group,control group took chlorpromazine and the observation group with benzodiazepine drugs（diazepam used）,both groups were given vitamins and psychotherapy. Results There were no significant differences in clinical symptoms,cognitive function,quality of life ,hospital days ,PANSS ,WCST and WHO. QOL-100 score between two groups before treatment （t= 0.75, P〉0. 05） ;after treatment,there were significant differences in PANSS,WCST and WHO. QOL-100 scores（t=6.48,P〈0.05）.Conclusion In spirit of patients with symptoms,cognitive function,the quality of life,the observation group restore faster than the control group, the effect of benzodiazepine drugs for chronic alcoholism with mental disorder is effective.

关 键 词：慢性酒精中毒 氯丙嗪 苯二氮类 地西泮 

分 类 号：R749[医药卫生—神经病学与精神病学]