米诺环素凝胶辅助治疗牙周炎的临床研究  

Clinical study of minocycline as adjunctive therapy in the treatment of periodontitis

作　　者：王姹[1] 徐燕[1] 李全利[2] 孙晓瑜[1] 

机构地区：[1]安徽医科大学附属口腔医院牙周黏膜科,合肥230022 [2]安徽医科大学附属口腔医院修复科,合肥230022

出　　处：《安徽医科大学学报》2012年第1期63-66,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省科技攻关项目(编号:08010302196);安徽省自然科学基金资助项目(编号:090413146);安徽省教育厅资助产学研项目(编号:KJ2010A159);安徽医科大学重点实验室项目(编号:2009-2010)

摘　　要：目的评价并比较米诺环素凝胶和派丽奥的缓释性能和临床疗效。方法将11位患者的22颗患牙随机分为两组:①龈下刮治和根面平整术(SRP)+米诺环素凝胶(实验组);②SRP+派丽奥(对照组),分别在治疗前和治疗后4周检查龈沟出血指数(SBI)、探诊深度(PD)、松动度(MOB)和龈沟液量4项临床指标;在牙周袋内用药后收集患牙龈沟液,测量牙周袋内的药物浓度。结果治疗后,实验组与对照组各临床指标相比差异无统计学意义;在牙周局部使用米诺环素凝胶后,第1天药物浓度为3.334 mg/L,以后释放速度逐渐下降,到第7天浓度为1.857 mg/L,使用派丽奥后,第1天的浓度为3.341 mg/L,到第7天降至0.714 mg/L,两种药物均可维持1周的有效药物浓度。结论米诺环素凝胶局部使用后可在牙周袋内缓慢释放,在辅助治疗牙周炎方面与派丽奥有相同的疗效,具有一定的临床应用价值。Objective To evaluate and compare the controlled-release characteristic and clinical effect of minocycline gel made in the research group and periocline as an adjunctive therapy to scaling and root planning（SRP） in periodontitis. Methods 22 tooth in 11 patients with moderate to advanced periodontitis were randomly divided into two groups： SRP plus minocycline gel（experimental group） and SRP plus periocline （control group）. All clinical parameters including sulcus bleeding index （ SBI）, probing depth （ PD）, mobility （MOB） and the quantity of gingival crevicular fluid were recorded before treatment and 4 weeks after treatment. The drug concentration in periodontal pocket was measured by collecting gingival crevieular fluid after drug use. Results All clinical parameters in two groups had no significant difference at 4 weeks after treatment; Two drugs released slowly after using in peri- odontal pocket and the effective drug concentration eould maintain for one week. The concentration of minocycline gel was 3. 334 mg/L at the first day and 1. 857 mg/L at the seventh day, while the concentration of perioeline fell from 3. 341 mg/L to 0. 714 mg/L. Conclusion Minoeyclin gel can release slowly in periodontal pocket and has a similar clinical effect and application value with periocline in the adjunctive therapy of chronic periodontitis.

关 键 词：米诺环素 龈沟液 牙周炎 

分 类 号：R781.4[医药卫生—口腔医学]