CD24在初诊结直肠癌患者外周血CD3^+细胞上表达的意义  

Significance of CD24 expression in CD3^+ cells of the peripheral blood in patient with newly diagnosed colorectal cancers

作　　者：谭冬梅 麦霓薇 胡淑芬 罗韬 朱剑霞 黄福喜 

机构地区：[1]广州市番禺区中心医院检验科,511400 [2]广州市番禺区中心医院肿瘤科,511400

出　　处：《中华实用诊断与治疗杂志》2012年第1期49-50,共2页Journal of Chinese Practical Diagnosis and Therapy

基　　金：广州市番禺区科技计划资助项目(2011-z-03-25)

摘　　要：目的探讨结直肠癌外周血CD3+细胞(荧光强度>104)中CD24的表达及其临床意义。方法 50例初诊结直肠癌患者(观察组)和50名健康体检者(对照组),均应用流式细胞术直接免疫荧光法检测外周血CD3+细胞上CD24的表达水平,比较2组CD3+细胞上CD24荧光强度。结果观察组外周血CD3+细胞上CD24荧光强度为373.02±27.92,对照组为293.84±9.54,2组比较差异有统计学意义(P<0.05)。结论结直肠癌患者外周血中CD3+细胞上CD24荧光强度可作为外周血中筛选结直肠癌的一个新的分子标志物。Objective To explore the expression of CD24 in CD3＋ cells（fluorescence intensity104） of the peripheral blood in patients with colorectal cancer and its clinical significance.Methods Fifty patients with newly diagnosed colorectal cancer（the observation group） and 50 healthy controls（control group） were detected the expression of CD24 in CD3＋ cells with direct immunofluorescence flow cytometry.The mean fluorescence intensity was compared between these two groups.Results The mean fluorescence intensity of CD24 in CD3＋ cells was 373.02±27.92 and 293.84±9.54 in the observation group and control group respectively,which showed a significant difference between two groups（P0.05）.Conclusion The fluorescence intensity of CD24 in CD3＋ cells may be a new molecular marker in colorectal cancer screening.

关 键 词：结直肠癌 CD24 CD3+ 流式细胞术 

分 类 号：R735.3[医药卫生—肿瘤]