SD大鼠自发性胰岛细胞癌伴多发性肝转移  

Spontaneous islet cell carcinoma with multiple liver metastases in a Sprague-Dawley rat

作　　者：柳云恩 姚宝玉 杨冬华 王捷 

机构地区：[1]国家沈阳新药安全评价研究中心,辽宁省沈阳市110141

出　　处：《世界华人消化杂志》2011年第31期3237-3241,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨SD大鼠罕见的自发性胰岛细胞癌伴多发性肝转移病例的生化表现和形态学特征,为研究该疾病提供理论参考.方法:致癌试验结束后,SD大鼠乙醚麻醉,进行腹主动脉采血,所采血液用于血常规和血液生化相关指标的检测;同时,对SD大鼠进行仔细的大体观察,并对病变组织进行取材,制成病理切片,进行形态学观察.结果:在致癌试验的104wk,雄性对照组SD大鼠胰腺上发现一个约为4.0*5.0cm大小的肿物.组织学检测发现,肿瘤细胞与正常胰岛细胞类似,但细胞排列方式多样,肿瘤压迫并侵袭间质血管和周围被膜;此外,在肝脏血窦和汇管区也发现多个转移灶.血液学结果表明,中性粒细胞绝对数(NEUT#:3.63×109/L)和相对数(NEUT%:42.00),均显著高于同周龄雄性SD大鼠正常参考值范围(1.13×109-2.55×109/L,16.01-27.77);血糖(Glu:2.07mmol/L),显著低于其同周龄雄性SD大鼠正常参考值范围(5.82-8.86mmol/L).结论:该肿瘤诊断为SD大鼠自发性胰岛细胞癌伴多发性肝转移.AIM：To analyze the biochemical and morphological characteristics of spontaneous islet cell carcinoma with multiple liver metastases in a Sprague-Dawley rat to provide a theoretical basis for the study of the disease.METHODS：The animal was anesthetized with ether at the end of a carcinogenicity study. Blood samples were collected via the abdominal aorta and used for hematology and serum biochemistry.Meanwhile,the animal was subjected to detailed gross observation,and all abnormal tissue samples were taken for histopathology examination.RESULTS：A pancreatic neoplasm measuring 4.05.0 cm was noted in a 104-wk-old male Sprague-Dawley rat which was used as a control in a carcinogenicity study.The tumor cells were similar to normal islet cells,but showed a highly variable pattern.The tumor compressed and invaded into the vessels and adjacent tissues.There were multiple foci of metastasis in portal areas and sinusoid of the liver.Neutrophil count（3.63×10 9 /L） and neutrophil percentage（42.00%） were significantly higher than the normal reference ranges.Blood glycogen（2.07 mmol/L） was significantly lower than the normal reference range. CONCLUSION：A spontaneous islet cell carcinoma with multiple liver metastases was diagnosed in a Sprague-Dawley rat.

关 键 词：SD大鼠 自发性胰岛细胞癌 转移 肝脏 

分 类 号：R736.7[医药卫生—肿瘤]