皮下软组织上皮样血管肉瘤2例临床病理观察  

Epithelioid angiosarcoma:clinical and pathologic analysis of two cases

作　　者：阳泽彬[1] 许琳[1] 

机构地区：[1]天津市公安医院病理科,天津300042

出　　处：《诊断病理学杂志》2011年第6期447-449,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨上皮样血管肉瘤(EAS)的临床病理特点、诊断和鉴别诊断。方法对2例上皮样血管肉瘤的组织病理学、免疫组化结果进行分析,结合文献进行讨论。结果镜下肿瘤由细胞体积大、胞质丰富、具有上皮样特征的瘤细胞构成。瘤细胞呈弥漫片状、腺管状、单排条索状排列。免疫组化:肿瘤细胞CD34和FⅧAg(+),AE1/AE3和EMA部分(+)。结论上皮样血管肉瘤是一种罕见的高度恶性肿瘤,诊断和鉴别诊断主要依赖其病理形态学特点结合免疫表型。Objective To investigate the clinical and pathologic features of epithelioid angiosarcoma（EAS）.Methods Two cases of EA were analyzed with pathological morphology and immunohistochemical staining and review of the related literature.Results Microscopically,the tumors were composed mostly of proliferating malignant cells with an epithelioid morphology.They had abundant eosinophilic cytoplasm,arranged in a predominantly sheetlike,and an occasional pseudoglandular or trabecular and cord patterns.Immunohistochemically,the tumor cells were positive for CD34 and FⅧAg,and part of them were positive for AE1/AE3 and EMA.Conclusion EA is a rare,high-grade sarcoma.The correct diagnosis is based on imaging and pathologic examination as well as immunophenotype labeling.

关 键 词：血管肉瘤 上皮样 病理学 鉴别诊断 

分 类 号：R732.2[医药卫生—肿瘤]