未治疗惊恐障碍患者脑结构和脑功能的磁共振研究  

MRI for brain structure and function in patients with first-episode panic disorder

作　　者：张燕[1] 段炼[1] 廖梅[1] 杨帆[1] 刘军[1] 单宝慈[2] 李凌江[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,长沙410011 [2]中国科学院高能物理研究所医学影像学实验室,北京100049

出　　处：《中南大学学报（医学版）》2011年第12期1170-1175,共6页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81101004;81171286;30830046);"973"课题(2009CB918303);教育部博士点基金(20090162110011);湖南省自然科学基金(10JJ6034)~~

摘　　要：目的:探讨未治疗惊恐障碍患者的脑结构和脑功能特点。方法:分别对24例惊恐障碍患者和健康对照者依次完成情绪计数Stroop任务的功能磁共振和三维结构磁共振扫描,应用优化的基于体素形态学(voxel-based morphology,VBM)方法分析脑灰质体积。结果:将加工惊恐词汇与中性词汇相比较,惊恐障碍患者组在左侧丘脑、左侧额叶内侧回、左侧前扣带回、左侧额下回、左侧岛叶较健康对照组激活不足;而在右侧脑干、右侧枕叶/舌回过度激活。惊恐障碍患者组左侧颞上回、右侧额叶内侧回、左侧枕中回、左侧丘脑背内侧核、右侧前扣带回比健康对照组的灰质体积降低。结论:惊恐障碍患者前扣带回功能出现抑制和弱化,选择性注意能力下降。Objective To determine the brain function and structure in patinets with first-episode panic disorder（PD）.Methods All subjects（24 PD patients and 24 healthy subjects） received MRI scan and emotional counting Stroop task during the functional magnetic resonance imaging.Blood oxygenation level dependent functional magnetic resonance imaging and voxel-based morphometric technology were used to detect the gray matter volume.Results Compared with the healthy controls,left thalamus,left medial frontal gyrus,left anterior cingulate gyrus,left inferior frontal gyrus,left insula（panic-related words vs.neutral words） lacked activation in PD patients,but the over-activation were found in right brain stem,right occipital lobe/lingual gyrus in PD patients.Compared with the healthy controls,the gray matter volume in the PD patients significantly decreased in the left superior temporal gyrus,right medial frontal gyrus,left medial occipital gyrus,dorsomedial nucleus of left thalamus and right anterior cingulate gyrus.There was no significantly increased gray matter volume in any brain area in PD patients.Conclusion PD patients have selective attentional bias in processing threatening information due to the depression and weakening of the frontal cingulated gyrus.

关 键 词：惊恐障碍 情绪计数Stroop 灰质体积 功能磁共振 

分 类 号：R749.7[医药卫生—神经病学与精神病学]