实时组织超声弹性成像与瞬时弹性成像评价慢性乙肝感染肝纤维化程度的对比研究  

Comparative study of real-time tissue elastography and FibroScan in evaluation of hepatic fibrosis

作　　者：孟繁坤[1] 郑颖[1] 徐晓鸾[1] 穆晓洁[1] 丁蕾[1] 

机构地区：[1]首都医科大学附属北京佑安医院超声科,北京市100069

出　　处：《临床超声医学杂志》2011年第12期807-809,共3页Journal of Clinical Ultrasound in Medicine

摘　　要：目的对比分析实时组织弹性成像(RTE)与瞬时弹性成像(FibroScan)在评价肝纤维化程度中的应用价值。方法对121例慢性乙肝感染患者进行经皮肝脏穿刺活检术病理组织学检查,分为S0～S4期,同时行RTE和Fi-broScan检查。将RTE检查中获取的9个弹性变量经多元逐步回归分析方程计算出肝纤维化指数(LF Index)值作为RTE指标,将FibroScan检查中获取的10次成功检查所得的弹性硬度值(Stiffness)作为FibroScan指标。结果随着S分期增加,LF Index和Stiffness值均逐渐增加,LFIndex和FibroScan指标与纤维化病理分期的相关系数分别为0.667和0.664。以S2期和S3期作为分界限,LF Index和Stiffness值ROC曲线下面积相近,分别为0.886、0.877和0.917、0.873。结论 RTE和FibroScan检查在判断肝纤维化程度方面的能力相近。To comparatively analyze the application value of realtime tissue elastography（RTE） and Fi- broScan in assessment of hepatic fibrosis. Methods One hundred and twentyone patients infected with chronic HBV were ex- amined by percutaneous hepatic biopsy, then they were graded into S0-S4, and simultaneously conducted with RTE and FibroScan. The liver fibrosis index （LF Index） calculated by 9 variables achieved with RTE in multivariate regression analysis was taken as RTE index. The elastic stiffness value （Stiffness） achieved in 10 successful FibroScan examinations was taken as FibroScan index. Results With S grading increased, the mean value of LF Index and Stiffness had a trend of gradual increasing. The correlation coefficient of RTE and FibroScan indexes with the fibrosis grading was 0. 667 and 0. 664. Taking S2 and S3 as a dividing line, the area under ROC curve of LF Index and Stiffness were 0. 886, 0. 877 and 0. 917, 0. 873 ,respectively. Conclu- sion RTE and FibroScan have similar role in determining hepatic fibrosis.

关 键 词：超声检查 弹性成像 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统] R445.1[医药卫生—内科学]