幽门螺杆菌感染与胃癌  

Helicobacter pylori infection and gastric cancer

作　　者：时昭红[1] 刘浩[1] 

机构地区：[1]武汉市第一医院消化内科,湖北省武汉市430022

出　　处：《世界华人消化杂志》2011年第32期3327-3331,共5页World Chinese Journal of Digestology

摘　　要：2005年的诺贝尔生理学和医学奖授予了幽门螺杆菌(Helicobacter pylori,H.pylori)的发现人巴里·马歇尔和罗宾·沃伦教授.迄今有大量的流行病学、临床和实验研究支持H.pylori是胃癌的致病因素,但其具体致病机制尚不完全明了.本文就H.pylori感染和胃癌的流行病学研究,H.pylori感染致胃癌的动物实验模型研究,H.pylori毒力基因与胃癌的关系,H.pylori感染与胃癌相关基因的关系和H.pylori感染与胃上皮细胞增殖和凋亡的关系等方面,系统阐述H.pylori感染和胃癌之间的关系.The 2005 Nobel Prize in Physiology and Medicine was awarded to Barry Marshall and Robin Warren for their discovery of Helicobacter pylori（H. pylori）.Now numerous epidemiological,clinical and experimental studies and reports emphasized the crucial role of H.pylori in the pathogenesis of gastric cancer（GC）,but the specific mechanism is still unknown.In this paper,we undertake a systematic review of H.pylori infection-related GC epidemiological studies,animal models of H.pylori infection-induced GC,the relationship between the virulence genes of H.pylori and GC,the links between H.pylori infection and genes related to GC,and the correlation of H.pylori infection with gastric epithelial proliferation and apoptosis.

关 键 词：幽门螺杆菌 胃癌 致病机制 

分 类 号：R735.2[医药卫生—肿瘤]