黄芩苷磷脂复合物基本性质研究  

Basic property of baicalin-phospholipid complex

作　　者：史亚军[1,2] 吴品江[1] 许润春[1] 林彦君[1] 马鸿雁[1] 杨明[1,3] 

机构地区：[1]成都中医药大学药学院,四川成都611137 [2]陕西中医学院药学院,陕西咸阳712046 [3]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《中草药》2012年第1期78-82,共5页Chinese Traditional and Herbal Drugs

基　　金：国家重大新药创制专项(2009ZX09103-353);陕西省教育厅科研专项资助(11JK0680)

摘　　要：目的考察黄芩苷与磷脂形成复合物的基本性质。方法对制备的黄芩苷磷脂复合物进行红外光谱、核磁共振氢谱、量子化学及其溶解性、透膜性能等方面研究。结果红外光谱研究表明黄芩苷磷脂复合物的图谱具有黄芩苷、大豆卵磷脂红外光谱的特征,与混合物的红外光谱图走势大体一致,没有明显差异,但图谱中-C=O、-N-H的峰形与波数均出现了变化;核磁共振氢谱结果表明磷脂复合物的形成并未在分子间产生新的化学键,但NMR谱中黄芩苷中羟基的峰形与化学位移同样发生了变异;量子化学研究表明两个分子之间虽未形成新的化合物,而是在空间匹配的前提下,以一种较弱的原子轨道重叠方式靠近在一起形成相对稳定的一种空间构象。形成复合物后对黄芩苷的溶解性改善显著,透膜累积渗透量大大提高。结论黄芩苷磷脂复合物的形成并未在分子间产生新的化学键,它们之间是以一种弱的相互作用力相结合,从而形成一种较为稳定的复合体,形成复合物后黄芩苷的理化性质和生物学特性有明显改善。Objective To investigate the basic property of baicalin complex with phospholipid.Methods To study the baicalin complex with phospholipid by means of IR,1H-NMR,quantum chemistry,dissolubility,and the property of permeation membrane.Results The result of IR indicated that spectrogram of baicalin complex with phospholipid had the same tendency in property with baicalin and mixture.While the peak shape and wave number of-C=O,-N-H appeared abnormal.The 1H-NMR indicated that the phospholipid complex did not produce new chemical bonds between the two molecules.But the peak shape and chemical shift produced a certain change.The quantum chemistry result revealed that the two molecules did not form new compounds.On the basis of space matching,the two formed a relatively stable spatial relation by a weaker atomic orbitals overlap method.The solubility of baicalin was significantly improved,the permeation membrane ratio of baicalin was boost.Conclusion The formation of baicalin-phospholipid complex does not produce new chemical bonds.The two form a relatively stable complex by some weak interaction force.The physicochemical properties and biological characteristics of the complex are greatly improved.

关 键 词：黄芩苷 磷脂复合物 红外光谱 核磁共振氢谱 量子化学 

分 类 号：R283.6[医药卫生—中药学]