经肱动脉插管持续灌注β-榄香烯乳治疗局部晚期乳腺癌疗效分析  

Efficacy Analysis of Treating Local Advanced Breast Cancer by Continuously Infusing β-elemene Milk Through Brachial Artery

作　　者：孟凡喆[1] 梅世伟[1] 郝淑芳[1] 梁晓聪[1] 刘文导[1] 杨志刚[1] 常钢[1] 

机构地区：[1]广东省中医院,广东广州510120

出　　处：《中华中医药学刊》2012年第1期124-125,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：广东省中医药局科技项目(2007329)

摘　　要：目的:评价中药榄香烯治疗乳腺癌的临床疗效及安全性,探索中药榄香烯抗肿瘤的新的介入给药途径。方法:经粗针穿刺组织病理证实为乳腺癌患者60例随机分成两组。治疗组(榄香烯组):榄香烯100mL经过股动脉,内乳区动脉注射于患瘤乳房,共1次。对照组(THP组):THP50mg/m2,经过股动脉,内乳区动脉注射于患瘤乳房,共1次。评价两组疗效及不良反应发生率。结果:术后7天两组有效率差异无统计学意义(P>0.05),术后3个月两组有效率分别为:76.6%7、0%,差异有统计学意义(P<0.05)。术后6个月两组有效率分别为:80%6、6.7%,差异有统计学意义(P<0.01)。治疗组术后7天、术后3个月KPS均比对照组高,差异有统计学意义(P<0.05)。治疗组不良反应发生率明显低于对照组(P<0.05)。结论:榄香烯持续灌注对乳腺癌在缩小乳腺肿块上有显著疗效,且能提高乳腺癌患者的生活质量,不良反应发生率低,值得临床推广。Objective： To evaluate the clinical efficacy and safety of treating breast cancer with elemene and to explore new administration route of anti-tumor medicine elemene through intervention.Methods： 60 cases of breast cancer patients,who were confirmed by pathology of thick needle punctured tissue,were randomly divided into two groups.Treatment group（elemene group）： 100mL elemene was injected into the breast with tumors through femoral artery and internal mammary artery;control group（THP group）： THP50mg/m2 was injected into the breast with tumors through femoral artery and internal mammary artery.There was only one time injection in both groups.Efficacy and incidence of adverse effects were evaluated for both groups.Results： 7 days after the operation,there was no significant statistical difference in efficacy between two groups（P0.05）,3 months after the operation,the efficacy rates of two groups were respectively 76.6% and 70%;the difference was statistically significant（P0.05）.6 months after the operation,the efficacy rates of two groups were respectively 80% and 66.7%;the difference was statistically significant（P0.01）.KPS of 7 days and 3 months after the operation in treatment group were both higher than that of control group,the difference was statistically significant（P0.05）.Incidence of adverse events in treatment group was significantly lower than that in the control group（P0.05）.Conclusion： The continuous infusion of elemene has a significant effect on reducing breast lumps of breast cancer patients,and can improve their life quality.Besides,the incidence of adverse events was much lower,therefore,this method is worthy of being clinically popularized.

关 键 词：乳腺癌 榄香烯 介入 

分 类 号：R737.9[医药卫生—肿瘤]