抗肿瘤药物在金属有机骨架中的装载及体外释放  

Loaded and in vitro Drug Release of Anticancer Drugs in Porous Metal-Organic Frameworks

作　　者：杨宝春[1] 姜耀东[2] 秦雪娟[1] 陈志良[1] 任非[1] 

机构地区：[1]南方医科大学南方医院药学部,广州510515 [2]南方医科大学南方医院泌尿外科,广州510515

出　　处：《高等学校化学学报》2012年第1期26-31,共6页Chemical Journal of Chinese Universities

基　　金：广东省科技计划(批准号:2008B060600068);南方医院院长基金(批准号:2009C012)资助

摘　　要：以三乙胺直接加入法制备金属-有机骨架MOF-5,采用X射线粉末衍射(XRD)、红外光谱(IR)和热重分析(TG)对所得样品进行表征.分别以辣椒素和5-氟尿嘧啶(5-Fluouourail,5-FU)为模型药物,研究了MOF-5对2种药物的载药及体外释药性能.通过将所得样品的XRD和IR谱图与标准谱图比对确定了样品的结构.TG结果表明,所制备的MOF-5热稳定性良好.MOF-5对辣椒素的最高载入量达0.592 g/g载体,对5-FU的最高载入量为0.315 g/g载体,两种载药体系的体外释药均为明显的两相模式.体外细胞毒性实验结果表明,MOF-5具有良好的生物相容性.Porous metal-organic frameworks（MOF-5） were synthesized and the structure of synthetic MOF-5 was confirmed by XRD and IR spectrum.According to the result of TG,the synthetic MOF-5 displayed better thermo-stabilization.The capsaicin or 5-fluouourail was loaded in synthetic MOF-5 and in vitro drug release profile were investigated,respectively.The highest drug loading rates are 0.592 g/g MOF for capsaicin and 0.315 g/g MOF for 5-FU in drug-loaded MOF-5,respectively.The in vitro drug release profile of both MOF-5 formulations showed a clear biphasic release pattern.Cytotoxicity test showed that MOF-5 displayed good biocompatility.

关 键 词：金属-有机骨架 辣椒素 5-氟尿嘧啶 载药量 药物缓释 细胞毒性 

分 类 号：O614[理学—无机化学] O636.9[理学—化学]